Carole A Sargent
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Explore the profile of Carole A Sargent including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Lopes A, Miguel R, Sargent C, Ellis P, Amorim A, Affara N
BMC Mol Biol
. 2010 May;
11:33.
PMID: 20459660
Background: The Y chromosome of mammals is particularly prone to accumulate genes related to male fertility. However, the high rate of molecular evolution on this chromosome predicts reduced power to...
12.
Lopes A, Burgoyne P, Ojarikre A, Bauer J, Sargent C, Amorim A, et al.
BMC Genomics
. 2010 Feb;
11:82.
PMID: 20122165
Background: X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number...
13.
Quilter C, Gilbert C, Oliver G, Jafer O, Furlong R, Blott S, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2008 Mar;
147B(7):1126-37.
PMID: 18361432
The etiology of mental disorders remains largely unclear. Complex interactions between genetic and environmental factors are key to the development of such disorders. Puerperal psychosis is the most extreme form...
14.
Quilter C, Blott S, Wilson A, Bagga M, Sargent C, Oliver G, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2007 May;
144B(7):862-8.
PMID: 17503476
Childbirth is a period of substantial rapid biological and psychological change and a wide range of psychotic disorders can occur ranging from mild 'baby blues' to severe episodes of psychotic...
15.
Blanco-Arias P, Sargent C, Affara N
Mamm Genome
. 2004 Apr;
15(4):296-306.
PMID: 15112107
Protocadherin X and Y (PCDHX/Y) represent a pair of homologous genes located on the human sex chromosomes that are primarily expressed in the brain. PCDHY emerged as a result of...
16.
Blanco-Arias P, Sargent C, Affara N
Mamm Genome
. 2004 Jan;
15(1):41-52.
PMID: 14727141
The gene-poor, hominid-specific Yp11.2/Xq21.3 X-Y homology block encodes two members of the protocadherin group of cell surface molecules, PCDHX and PCDHY. These two genes, mainly expressed in brain, were known...
17.
Hall N, Brown G, Furlong R, Sargent C, Mitchell M, Rocha D, et al.
Mamm Genome
. 2003 Aug;
14(7):437-47.
PMID: 12925892
Sequences complementary to the X-linked ubiquitin-specific protease gene Usp9x (Dffrx) have been shown to map to the Sxr(b) interval of the mouse Y Chromosome (chr) and to be expressed in...
18.
Ross N, Mavrogiannis L, Sargent C, Knight S, Wadekar R, DeLisi L, et al.
Psychiatr Genet
. 2003 Jun;
13(2):115-9.
PMID: 12782970
Objectives: The genetic basis of schizophrenia is obscure. In an XX male patient with schizophrenia we previously showed that one X;Y translocation breakpoint was in pseudoautosomal region 1 (PAR1) with...
19.
Quilter C, Blott S, Mileham A, Affara N, Sargent C, Griffin D
Mamm Genome
. 2002 Nov;
13(10):588-94.
PMID: 12420137
A combination of FISH and RH mapping was used to study the evolution of sex chromosome genes in the pig. In total, 19 genes were identified, including 3 PAR genes...
20.
Blanco-Arias P, Sargent C, Affara N
Mamm Genome
. 2002 Sep;
13(8):463-8.
PMID: 12226713
Yp11.2/Xq21.3 is a human-specific homology block that constitutes the largest shared region among the sex chromosomes, spanning some 3.5 Mb. Only two transcribed sequences have been mapped to this segment:...