Alan Mileham
Overview
Explore the profile of Alan Mileham including associated specialties, affiliations and a list of published articles.
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13
Citations
464
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Recent Articles
1.
Whitworth K, Rowland R, Petrovan V, Sheahan M, Cino-Ozuna A, Fang Y, et al.
Transgenic Res
. 2018 Oct;
28(1):21-32.
PMID: 30315482
The alphacoronaviruses, transmissible gastroenteritis virus (TGEV) and Porcine epidemic diarrhea virus (PEDV) are sources of high morbidity and mortality in neonatal pigs, a consequence of dehydration caused by the infection...
2.
Prather R, Wells K, Whitworth K, Kerrigan M, Samuel M, Mileham A, et al.
Sci Rep
. 2017 Oct;
7(1):13371.
PMID: 29042674
After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include...
3.
Park K, Powell A, Sandmaier S, Kim C, Mileham A, Donovan D, et al.
Sci Rep
. 2017 Feb;
7:42458.
PMID: 28195163
The domestic pig is an important "dual purpose" animal model for agricultural and biomedical applications. There is an emerging consensus in the biomedical community for the use of large animal...
4.
Park K, Kaucher A, Powell A, Waqas M, Sandmaier S, Oatley M, et al.
Sci Rep
. 2017 Jan;
7:40176.
PMID: 28071690
Genome editing tools have revolutionized the generation of genetically modified animals including livestock. In particular, the domestic pig is a proven model of human physiology and an agriculturally important species....
5.
Popescu L, Gaudreault N, Whitworth K, Murgia M, Nietfeld J, Mileham A, et al.
Virology
. 2016 Nov;
501:102-106.
PMID: 27898335
African swine fever is a highly contagious, often fatal disease of swine for which there is no vaccine or other curative treatment. The macrophage marker, CD163, is a putative receptor...
6.
Wells K, Bardot R, Whitworth K, Trible B, Fang Y, Mileham A, et al.
J Virol
. 2016 Nov;
91(2).
PMID: 27847356
Importance: Genetic modification of the CD163 gene creates the opportunity to develop production animals that are resistant to PRRS, the costliest viral disease to ever face the swine industry. The...
7.
Bayram H, Claydon A, Brownridge P, Hurst J, Mileham A, Stockley P, et al.
J Proteomics
. 2016 Jan;
135:38-50.
PMID: 26768581
Unlabelled: Many proteomics studies are conducted in model organisms for which fully annotated, detailed, high quality proteomes are available. By contrast, many studies in ecology and evolution are conducted in...
8.
Whitworth K, Lee K, Benne J, Beaton B, Spate L, Murphy S, et al.
Biol Reprod
. 2014 Aug;
91(3):78.
PMID: 25100712
Targeted modification of the pig genome can be challenging. Recent applications of the CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a designed CRISPR/Cas9 system targeting...
9.
Robert C, Fuentes-Utrilla P, Troup K, Loecherbach J, Turner F, Talbot R, et al.
BMC Genomics
. 2014 Jul;
15:550.
PMID: 24988888
Background: The domestic pig (Sus scrofa) is both an important livestock species and a model for biomedical research. Exome sequencing has accelerated identification of protein-coding variants underlying phenotypic traits in...
10.
Masopust M, Vykoukalova Z, Knoll A, Bartenschlager H, Mileham A, Deeb N, et al.
Mol Biol Rep
. 2010 Nov;
38(4):2611-7.
PMID: 21104145
Using PCR and inverse PCR techniques we obtained a 4,498 bp nucleotide sequence FN424076 encompassing the complete coding sequence of the porcine insulin receptor substrate 4 (IRS4) gene and its...