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Carol L Roberts

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Recent Articles
1.
Simpson H, Roberts C, Thompson L, Leiper C, Gittens N, Trotter E, et al.
Front Pharmacol . 2021 Dec; 12():766293. PMID: 34955836
infection (CDI) is a leading cause of antibiotic-associated diarrhoea. Adhesion of this Gram-positive pathogen to the intestinal epithelium is a crucial step in CDI, with recurrence and relapse of disease...
2.
Dogan B, Suzuki H, Herlekar D, Sartor R, Campbell B, Roberts C, et al.
Inflamm Bowel Dis . 2014 Sep; 20(11):1919-32. PMID: 25230163
Background: Perturbations of the intestinal microbiome, termed dysbiosis, are linked to intestinal inflammation. Isolation of adherent-invasive Escherichia coli (AIEC) from intestines of patients with Crohn's disease (CD), dogs with granulomatous...
3.
Parsons B, Wigley P, Simpson H, Williams J, Humphrey S, Salisbury A, et al.
PLoS One . 2014 Feb; 9(2):e87658. PMID: 24498347
Soluble fibres (non-starch polysaccharides, NSP) from edible plants but particularly plantain banana (Musa spp.), have been shown in vitro and ex vivo to prevent various enteric pathogens from adhering to,...
4.
Prorok-Hamon M, Friswell M, Alswied A, Roberts C, Song F, Flanagan P, et al.
Gut . 2013 Jul; 63(5):761-70. PMID: 23846483
Objective: Colonic mucosa-associated Escherichia coli are increased in Crohn's disease (CD) and colorectal cancer (CRC). They variously haemagglutinate, invade epithelial cell lines, replicate within macrophages, translocate across M (microfold) cells...
5.
Roberts C, Rushworth S, Richman E, Rhodes J
J Crohns Colitis . 2013 Jan; 7(4):338-41. PMID: 23360575
Crohn's disease (CD) incidence has increased over the past fifty years but the explanation is unclear. CD can be brought into remission by liquid enteral feeding, but the mechanism for...
6.
Roberts C, Keita A, Parsons B, Prorok-Hamon M, Knight P, Winstanley C, et al.
J Nutr Biochem . 2012 Jul; 24(1):97-103. PMID: 22818716
Dietary fibres may have prebiotic effects mediated by promotion of beneficial bacteria. This study explores the possibility that soluble plant fibre may also improve health by inhibiting epithelial adhesion and...
7.
Roberts C, Keita A, Duncan S, OKennedy N, Soderholm J, Rhodes J, et al.
Gut . 2010 Sep; 59(10):1331-9. PMID: 20813719
Background: Crohn's disease is common in developed nations where the typical diet is low in fibre and high in processed food. Primary lesions overlie Peyer's patches and colonic lymphoid follicles...
8.
Subramanian S, Roberts C, Hart C, Martin H, Edwards S, Rhodes J, et al.
Antimicrob Agents Chemother . 2007 Dec; 52(2):427-34. PMID: 18070962
There is increasing evidence that Escherichia coli organisms are important in Crohn's disease (CD) pathogenesis. In CD tissue they are found within macrophages, and the adherent-invasive CD ileal E. coli...
9.
Subramanian S, Rhodes J, Hart C, Tam B, Roberts C, Smith S, et al.
Inflamm Bowel Dis . 2007 Oct; 14(2):162-75. PMID: 17941093
Background: Mucosally adherent E. coli are found in inflammatory bowel disease (IBD) and colon cancer. They promote release of the proinflammatory cytokine interleukin-8 (IL-8). We explored mechanisms for this release...
10.
Mpofu C, Campbell B, Subramanian S, Marshall-Clarke S, Hart C, Cross A, et al.
Gastroenterology . 2007 Oct; 133(5):1487-98. PMID: 17919633
Background & Aims: Crohn's disease (CD) is mimicked by inherited phagocyte disorders and is associated with circulating antibodies against yeast mannan (anti-Saccharomyces cerevisiae antibody; ASCA). We speculated that mannans might...