Carlos Martinez-Fleites
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Explore the profile of Carlos Martinez-Fleites including associated specialties, affiliations and a list of published articles.
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23
Citations
741
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Recent Articles
1.
Sharp S, Martella M, DAgostino S, Milton C, Ward G, Woodhead A, et al.
Nat Commun
. 2025 Feb;
15(1):10037.
PMID: 40016190
Eukaryotic initiation factor 4E (eIF4E) serves as a regulatory hub for oncogene-driven protein synthesis and is considered a promising anticancer target. Here we screen a fragment library against eIF4E and...
2.
Brennan P, Saunders R, Spanou M, Serafini M, Sun L, Heger G, et al.
bioRxiv
. 2024 Apr;
PMID: 38559242
Immunomodulatory imide drugs (IMiDs) including thalidomide, lenalidomide, and pomalidomide, can be used to induce degradation of a protein of interest that is fused to a short zinc finger (ZF) degron...
3.
Brayshaw L, Martinez-Fleites C, Athanasopoulos T, Southgate T, Jespers L, Herring C
RSC Med Chem
. 2021 May;
12(3):330-352.
PMID: 34046619
Cell and gene therapies have achieved impressive results in the treatment of rare genetic diseases using gene corrected stem cells and haematological cancers using chimeric antigen receptor T cells. However,...
4.
McMillan D, Martinez-Fleites C, Porter J, Fox 3rd D, Davis R, Mori P, et al.
Nat Commun
. 2021 Jan;
12(1):582.
PMID: 33495441
Tumour necrosis factor (TNF) is a trimeric protein which signals through two membrane receptors, TNFR1 and TNFR2. Previously, we identified small molecules that inhibit human TNF by stabilising a distorted...
5.
Spadiut O, Ibatullin F, Peart J, Gullfot F, Martinez-Fleites C, Ruda M, et al.
J Am Chem Soc
. 2011 May;
133(28):10892-900.
PMID: 21618981
The current drive for applications of biomass-derived compounds, for energy and advanced materials, has led to a resurgence of interest in the manipulation of plant polymers. The xyloglucans, a family...
6.
Nielsen M, Suits M, Yang M, Barry C, Martinez-Fleites C, Tailford L, et al.
J Biol Chem
. 2011 Feb;
286(17):15155-64.
PMID: 21288903
The enzymatic transfer of the sugar mannose from activated sugar donors is central to the synthesis of a wide range of biologically significant polysaccharides and glycoconjugates. In addition to their...
7.
Davies G, Martinez-Fleites C
Biochem Soc Trans
. 2010 Sep;
38(5):1179-88.
PMID: 20863281
Carbohydrates, their structures and the enzymes responsible for their synthesis and degradation, offer numerous possibilities for the design and application of probes with which to study and treat disease. The...
8.
Martinez-Fleites C, Smith N, Turkenburg J, Black G, Taylor E
Acta Crystallogr Sect F Struct Biol Cryst Commun
. 2009 Oct;
65(Pt 10):963-6.
PMID: 19850999
The crystal structures of truncated forms of the Streptococcus pyogenes phage-encoded hyaluronate lyases HylP2 and HylP3 were determined by molecular replacement to 1.6 and 1.9 A resolution, respectively. The truncated...
9.
Martinez-Fleites C, He Y, Davies G
Biochim Biophys Acta
. 2009 Aug;
1800(2):122-33.
PMID: 19647042
In order to study the O-GlcNAc modification in vivo, it is evident that a range of specific small molecule inhibitors would be a valuable asset. One strategy for the design...
10.
Martinez-Fleites C, Korczynska J, Davies G, Cope M, Turkenburg J, Taylor E
Carbohydr Res
. 2009 Jul;
344(13):1753-7.
PMID: 19595298
Lysozymes are found in many of the sequence-based families of glycoside hydrolases (www.cazy.org) where they show considerable structural and mechanistic diversity. Lysozymes from glycoside hydrolase family GH25 adopt a (alpha/beta)(5)(beta)(3)-barrel-like...