Carla Perego
Overview
Explore the profile of Carla Perego including associated specialties, affiliations and a list of published articles.
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Articles
45
Citations
963
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Recent Articles
1.
Galli A, Moretti S, Dule N, Di Cairano E, Castagna M, Marciani P, et al.
Am J Physiol Endocrinol Metab
. 2024 May;
327(1):E27-E41.
PMID: 38690938
Pancreatic endocrine cells employ a sophisticated system of paracrine and autocrine signals to synchronize their activities, including glutamate, which controls hormone release and β-cell viability by acting on glutamate receptors...
2.
Folli F, Finzi G, Manfrini R, Galli A, Casiraghi F, Centofanti L, et al.
Am J Physiol Endocrinol Metab
. 2023 Sep;
325(5):E595-E609.
PMID: 37729025
Simultaneous activation of the incretin G-protein-coupled receptors (GPCRs) via unimolecular dual-receptor agonists (UDRA) has emerged as a new therapeutic approach for type 2 diabetes. Recent studies also advocate triple agonism...
3.
Galli A, Arunagiri A, Dule N, Castagna M, Marciani P, Perego C
Biomolecules
. 2023 Feb;
13(2).
PMID: 36830593
Pancreatic β-cells, by secreting insulin, play a key role in the control of glucose homeostasis, and their dysfunction is the basis of diabetes development. The metabolic milieu created by high...
4.
Pancreatic PCSK9 controls the organization of the β-cell secretory pathway via LDLR-cholesterol axis
Marku A, Da Dalt L, Galli A, Dule N, Corsetto P, Rizzo A, et al.
Metabolism
. 2022 Aug;
136:155291.
PMID: 35981632
Background: Cholesterol is central to pancreatic β-cell physiology and alterations of its homeostasis contribute to β-cell dysfunction and diabetes. Proper intracellular cholesterol levels are maintained by different mechanisms including uptake...
5.
Iovino L, Giusti V, Pischedda F, Giusto E, Plotegher N, Marte A, et al.
Acta Neuropathol
. 2022 May;
144(1):81-106.
PMID: 35596783
The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic processes. EAAT2 function is finely regulated by endocytic events,...
6.
Perego C, Di Cairano E, Galli A, Moretti S, Bazzigaluppi E, Centonze V, et al.
Pharmacol Res
. 2022 Feb;
177:106130.
PMID: 35151858
Islet cell surface autoantibodies were previously found in subjects with type 1 diabetes mellitus (T1DM), but their target antigens and pathogenic mechanisms remain elusive. The glutamate transporter solute carrier family...
7.
Marku A, Galli A, Marciani P, Dule N, Perego C, Castagna M
Cells
. 2021 Nov;
10(11).
PMID: 34831062
Iron is an essential element involved in a variety of physiological functions. In the pancreatic beta-cells, being part of Fe-S cluster proteins, it is necessary for the correct insulin synthesis...
8.
Galli A, Marciani P, Marku A, Ghislanzoni S, Bertuzzi F, Rossi R, et al.
Biomedicines
. 2020 Dec;
8(12).
PMID: 33302345
Substantial epidemiological evidence indicates that a diet rich in polyphenols protects against developing type 2 diabetes. The phenylethanoid glycoside verbascoside/acteoside, a widespread polyphenolic plant compound, has several biological properties including...
9.
Maffioli E, Galli A, Nonnis S, Marku A, Negri A, Piazzoni C, et al.
Front Cell Dev Biol
. 2020 Aug;
8:508.
PMID: 32850772
Recently, using cluster-assembled zirconia substrates with tailored roughness produced by supersonic cluster beam deposition, we demonstrated that β cells can sense nanoscale features of the substrate and can translate these...
10.
Marku A, Carrion M, Pischedda F, Marte A, Casiraghi Z, Marciani P, et al.
Sci Rep
. 2020 Mar;
10(1):3799.
PMID: 32123243
The LRRK2 protein consists of multiple functional domains, including protein-binding domains at its N and C-terminus. Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) have been linked to familial...