Carla Carcasona
Overview
Explore the profile of Carla Carcasona including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
80
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Recent Articles
1.
Aparici M, Carcasona C, Ramos I, Montero J, Otal R, Ortiz J, et al.
J Pharmacol Exp Ther
. 2019 May;
370(1):127-136.
PMID: 31085697
AZD8871 is a novel muscarinic antagonist and -adrenoceptor agonist in development for chronic obstructive pulmonary disease. This study describes the pharmacological profile of AZD8871 in in vitro and in vivo...
2.
Roberts R, Sevilla S, Ferrer M, Taltavull J, Hernandez B, Segarra V, et al.
J Med Chem
. 2018 Mar;
61(6):2472-2489.
PMID: 29502405
Rational design of a novel template of naphthyridinones rapidly led to PDE4 inhibitors with subnanomolar enzymatic potencies. X-ray crystallography confirmed the binding mode of this novel template. We achieved compounds...
3.
Aparici M, Carcasona C, Ramos I, Montero J, Ortiz J, Cortijo J, et al.
Pulm Pharmacol Ther
. 2017 Jul;
46:1-10.
PMID: 28729041
LAS190792 is a novel muscarinic antagonist and β-adrenoceptor agonist in development for chronic respiratory diseases. This study investigated the pharmacological profile of LAS190792 in comparison to batefenterol, tiotropium, indacaterol and...
4.
Tarrason G, Carcasona C, Eichhorn P, Perez B, Gavalda A, Godessart N
Exp Dermatol
. 2017 Jun;
26(11):1105-1111.
PMID: 28605064
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new...
5.
Gracia J, Buil M, Castro J, Eichhorn P, Ferrer M, Gavalda A, et al.
J Med Chem
. 2016 Dec;
59(23):10479-10497.
PMID: 27933955
Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl cyclase. Its intracellular levels are tightly controlled by...
6.
Aparici M, Gavalda A, Ramos I, Carcasona C, Otal R, Fernandez-Blanco J, et al.
Eur J Pharmacol
. 2015 Dec;
770:61-9.
PMID: 26656755
Abediterol is a novel long-acting β2-adrenoceptor agonist (LABA) currently in development for once-daily combination maintenance therapy of asthma and COPD. This study investigated the preclinical profile of abediterol in terms...
7.
Gavalda A, Ramos I, Carcasona C, Calama E, Otal R, Montero J, et al.
Pulm Pharmacol Ther
. 2014 Jun;
28(2):114-21.
PMID: 24928173
This study characterised the in vitro and in vivo profiles of two novel long-acting muscarinic antagonists, aclidinium bromide and glycopyrronium bromide, using tiotropium bromide and ipratropium bromide as comparators. All...
8.
Aparici M, Gomez-Angelats M, Vilella D, Otal R, Carcasona C, Vinals M, et al.
J Pharmacol Exp Ther
. 2012 May;
342(2):497-509.
PMID: 22588259
Abediterol is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows subnanomolar affinity for the human β(2)-adrenoceptor and...
9.
Perez D, Crespo M, Sole L, Prat M, Carcasona C, Calama E, et al.
Bioorg Med Chem Lett
. 2011 Feb;
21(5):1545-8.
PMID: 21277205
The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β(1)/β(2)-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and...
10.
Gavalda A, Miralpeix M, Ramos I, Otal R, Carreno C, Vinals M, et al.
J Pharmacol Exp Ther
. 2009 Aug;
331(2):740-51.
PMID: 19710368
Aclidinium bromide is a novel potent, long-acting inhaled muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease. Aclidinium showed subnanomolar affinity for the five human muscarinic receptors...