Carla A M Lopes
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Explore the profile of Carla A M Lopes including associated specialties, affiliations and a list of published articles.
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8
Citations
304
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Recent Articles
1.
Di Nardo A, Lenoel I, Winden K, Ruhmkorf A, Modi M, Barrett L, et al.
Cell Rep
. 2020 Jun;
31(12):107780.
PMID: 32579942
Tuberous sclerosis complex (TSC) is a neurogenetic disorder that leads to elevated mechanistic targeting of rapamycin complex 1 (mTORC1) activity. Cilia can be affected by mTORC1 signaling, and ciliary deficits...
2.
Peneda C, Lopes C, Bettencourt-Dias M
Methods Mol Biol
. 2019 Dec;
2101:147-162.
PMID: 31879903
Centrioles assemble centrosomes and cilia/flagella, which are microtubule-based structures with key roles in cell division, polarity, motility, and signaling. Centriole biogenesis is a tightly regulated process, and deregulation of centriole...
3.
Lopes C, Mesquita M, Cunha A, Cardoso J, Carapeta S, Laranjeira C, et al.
J Cell Biol
. 2018 May;
217(7):2353-2363.
PMID: 29739803
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics of such abnormalities in human cancer are not known. In this study, we examined centrosomes in...
4.
Lopes C, Jana S, Cunha-Ferreira I, Zitouni S, Bento I, Duarte P, et al.
Dev Cell
. 2015 Oct;
35(2):222-35.
PMID: 26481051
Centrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control. Here, we show that...
5.
Jerman S, Ward H, Lee R, Lopes C, Fry A, Macdougall M, et al.
PLoS One
. 2014 Sep;
9(9):e106330.
PMID: 25180832
Mutation of the X-linked oral-facial-digital syndrome type 1 (OFD1) gene is embryonic lethal in males and results in craniofacial malformations and adult onset polycystic kidney disease in females. While the...
6.
Thauvin-Robinet C, Lee J, Lopez E, Herranz-Perez V, Shida T, Franco B, et al.
Nat Genet
. 2014 Jul;
46(8):905-11.
PMID: 24997988
Centrioles are microtubule-based, barrel-shaped structures that initiate the assembly of centrosomes and cilia. How centriole length is precisely set remains elusive. The microcephaly protein CPAP (also known as MCPH6) promotes...
7.
Lopes C, Prosser S, Romio L, Hirst R, OCallaghan C, Woolf A, et al.
J Cell Sci
. 2011 Jan;
124(Pt 4):600-12.
PMID: 21266464
Ciliopathies are caused by mutations in genes encoding proteins required for cilia organization or function. We show through colocalization with PCM-1, that OFD1 (the product of the gene mutated in...
8.
Hames R, Hames R, Prosser S, Euteneuer U, Lopes C, Moore W, et al.
Exp Cell Res
. 2007 Dec;
314(3):574-89.
PMID: 18068700
In many animals, the germ line develops from a distinct mitochondria-rich region of embryonic cytoplasm called the germ plasm. However, the protein composition of germ plasm and its formation remain...