Camilla Gustafsen
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Explore the profile of Camilla Gustafsen including associated specialties, affiliations and a list of published articles.
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20
Citations
663
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Recent Articles
1.
Skeldal S, Voss L, Lende J, Pedersen S, Molgaard S, Kaas M, et al.
J Biol Chem
. 2023 Jul;
299(9):105102.
PMID: 37507021
The Vps10p domain receptor SorCS2 is crucial for the development and function of the nervous system and essential for brain-derived neurotrophic factor (BDNF)-induced changes in neuronal morphology and plasticity. SorCS2...
2.
Skeby C, Hummelgaard S, Gustafsen C, Petrillo F, Frederiksen K, Olsen D, et al.
Kidney Int
. 2023 Jul;
104(4):754-768.
PMID: 37406929
Proteinuria is a prominent feature of chronic kidney disease. Interventions that reduce proteinuria slow the progression of chronic kidney disease and the associated risk of cardiovascular disease. Here, we propose...
3.
Hummelgaard S, Vilstrup J, Gustafsen C, Glerup S, Weyer K
Pharmacol Ther
. 2023 Jun;
249:108480.
PMID: 37331523
Lowering blood cholesterol levels efficiently reduces the risk of developing atherosclerotic cardiovascular disease (ASCVD), including coronary artery disease (CAD), which is the main cause of death worldwide. CAD is caused...
4.
Parn A, Olsen D, Tuvikene J, Kaas M, Borisova E, Bilgin M, et al.
Front Mol Neurosci
. 2023 Feb;
15:1084633.
PMID: 36733269
PCSK9 induces lysosomal degradation of the low-density lipoprotein (LDL) receptor (LDLR) in the liver, hereby preventing removal of LDL cholesterol from the circulation. Accordingly, PCSK9 inhibitory antibodies and siRNA potently...
5.
Pallesen L, Gustafsen C, Cramer J, Petersen S, Thirup S, Madsen P, et al.
Mol Cell Biol
. 2019 Nov;
40(3).
PMID: 31767632
The multifunctional type 1 receptor sortilin is involved in endocytosis and intracellular transport of ligands. The short intracellular domain of sortilin binds several cytoplasmic adaptor proteins (e.g., the AP-1 complex...
6.
Madsen P, Isaksen T, Siupka P, Toth A, Nyegaard M, Gustafsen C, et al.
Sci Rep
. 2019 Jan;
9(1):611.
PMID: 30679749
SorLA and Sortilin are multifunctional receptors involved in endocytosis and intracellular sorting of different and unrelated ligands. SorLA has recently attracted much attention as a novel strong risk gene for...
7.
Rasmussen L, Bottcher M, Ivarsen P, Jorgensen H, Nyegaard M, Buttenschon H, et al.
Nephrol Dial Transplant
. 2018 Aug;
35(4):632-639.
PMID: 30137516
Background: Chronic kidney disease is a risk factor for premature development of coronary atherosclerosis and mortality. A high level of proprotein convertase subtilisin/kexin type 9 (PCSK9) is a recently recognized...
8.
Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, et al.
Nat Commun
. 2017 Sep;
8(1):503.
PMID: 28894089
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by...
9.
Mehmedbasic A, Christensen S, Nilsson J, Ruetschi U, Gustafsen C, Poulsen A, et al.
J Biol Chem
. 2014 Dec;
290(6):3359-76.
PMID: 25525276
SorLA is a neuronal sorting receptor that is genetically associated with Alzheimer disease. SorLA interacts directly with the amyloid precursor protein (APP) and affects the processing of the precursor, leading...
10.
Glerup S, Olsen D, Vaegter C, Gustafsen C, Sjoegaard S, Hermey G, et al.
Neuron
. 2014 Jun;
82(5):1074-87.
PMID: 24908487
Balancing trophic and apoptotic cues is critical for development and regeneration of neuronal circuits. Here we identify SorCS2 as a proneurotrophin (proNT) receptor, mediating both trophic and apoptotic signals in...