Calvin C Chan
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Explore the profile of Calvin C Chan including associated specialties, affiliations and a list of published articles.
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14
Citations
333
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Recent Articles
1.
Woodie L, Melink L, Alberto A, Burrows M, Fortin S, Chan C, et al.
Mol Metab
. 2023 Dec;
79:101861.
PMID: 38142970
Objective: The dorsal vagal complex (DVC) of the hindbrain is a major point of integration for central and peripheral signals that regulate a wide variety of metabolic functions to maintain...
2.
Damen M, Stankiewicz T, Park S, Helsley R, Chan C, Moreno-Fernandez M, et al.
Int J Obes (Lond)
. 2021 Jul;
45(11):2377-2387.
PMID: 34302121
Objective: The risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα regulates...
3.
Chan C, Harley I, Pfluger P, Trompette A, Stankiewicz T, Allen J, et al.
Nat Commun
. 2021 May;
12(1):2911.
PMID: 34006859
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitously uncovered a role...
4.
Moreno-Fernandez M, Giles D, Oates J, Chan C, Damen M, Doll J, et al.
Cell Metab
. 2021 May;
33(6):1187-1204.e9.
PMID: 34004162
Emerging evidence suggests a key contribution to non-alcoholic fatty liver disease (NAFLD) pathogenesis by Th17 cells. The pathogenic characteristics and mechanisms of hepatic Th17 cells, however, remain unknown. Here, we...
5.
Chan C, Damen M, Moreno-Fernandez M, Stankiewicz T, Cappelletti M, Alarcon P, et al.
Nat Commun
. 2020 Jun;
11(1):2745.
PMID: 32488081
White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation in disease pathogenesis remain...
6.
Chan C, Damen M, Alarcon P, Sanchez-Gurmaches J, Divanovic S
J Interferon Cytokine Res
. 2019 Mar;
39(8):459-471.
PMID: 30920343
Comprehension of adipocyte function has evolved beyond a long-held belief of their inert nature, as simple energy storing and releasing cells. Adipocytes, including white, brown, and beige, are capable mediators...
7.
Zhang C, Seo J, Murakami K, Salem E, Bernhard E, Borra V, et al.
Nat Commun
. 2018 Sep;
9(1):3658.
PMID: 30201950
RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic...
8.
Mukherjee R, Moreno-Fernandez M, Giles D, Cappelletti M, Stankiewicz T, Chan C, et al.
Hepatol Commun
. 2018 May;
2(5):546-560.
PMID: 29761170
Nonalcoholic fatty liver disease (NAFLD) represents a disease spectrum ranging from benign steatosis to life-threatening cirrhosis and hepatocellular carcinoma. Elevated levels of reactive oxygen species (ROS) and exacerbated inflammatory responses...
9.
Cappelletti M, Lawson M, Chan C, Wilburn A, Divanovic S
J Leukoc Biol
. 2018 Jan;
103(3):535-543.
PMID: 29345344
Preterm birth (PTB) is the leading cause of neonatal mortality worldwide. Infection and inflammation are considered main causes of PTB. Among multiple pathogens, Gram-positive bacteria are commonly linked with induction...
10.
Giles D, Moreno-Fernandez M, Stankiewicz T, Graspeuntner S, Cappelletti M, Wu D, et al.
Nat Med
. 2017 Oct;
23(10):1241.
PMID: 28985207
This corrects the article DOI: 10.1038/nm.4346.