Caleb A Class
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Explore the profile of Caleb A Class including associated specialties, affiliations and a list of published articles.
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26
Citations
580
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Recent Articles
1.
Cooper D, Erkina T, Broyles B, Class C, Erkine A
iScience
. 2024 Nov;
27(11):111057.
PMID: 39524347
Transcriptional activation domains (ADs) of gene activators have remained enigmatic for decades as short, extremely variable, and structurally disordered sequences. Using a rational design and high throughput experimentation, we determine...
2.
Erkine A, Oliveira M, Class C
J Mol Biol
. 2024 Aug;
436(22):168766.
PMID: 39214280
Activation domains (ADs) of eukaryotic gene activators remain enigmatic for decades as short, extremely variable sequences which often are intrinsically disordered in structure and interact with an uncertain number of...
3.
Class C, Lukan C, Bristow C, Do K
Bioinformatics
. 2022 Nov;
39(1).
PMID: 36440915
Summary: The NanoTube is an open-source pipeline that simplifies the processing, quality control, normalization and analysis of NanoString nCounter gene expression data. It is implemented in an extensible R library,...
4.
Wei Y, Kanagal-Shamanna R, Zheng H, Bao N, Lockyer P, Class C, et al.
Leukemia
. 2022 Jun;
36(8):2097-2107.
PMID: 35697791
Loss-of-function TET2 mutations are recurrent somatic lesions in chronic myelomonocytic leukemia (CMML). KDM6B encodes a histone demethylase involved in innate immune regulation that is overexpressed in CMML. We conducted genomic...
5.
Kundu S, Rodriguez B, Gibson L, Warner A, Perez M, Bajaj R, et al.
Genes Dev
. 2022 Jun;
36(9-10):582-600.
PMID: 35654454
One of the mechanisms by which cancer cells acquire hyperinvasive and migratory properties with progressive loss of epithelial markers is the epithelial-to-mesenchymal transition (EMT). We have previously reported that in...
6.
Thongon N, Ma F, Santoni A, Marchesini M, Fiorini E, Rose A, et al.
Nat Commun
. 2021 Nov;
12(1):6850.
PMID: 34824242
The molecular mechanisms that drive hematopoietic stem cell functional decline under conditions of telomere shortening are not completely understood. In light of recent advances in single-cell technologies, we sought to...
7.
White M, Sloane R, Witt R, Reuben A, Gaudreau P, Andrews M, et al.
Oncoimmunology
. 2021 Nov;
10(1):1992880.
PMID: 34777916
Targeted and immunotherapy regimens have revolutionized the treatment of advanced melanoma patients. Despite this, only a subset of patients respond durably. Recently, combination strategies of BRAF/MEK inhibitors with immune checkpoint...
8.
Broyles B, Gutierrez A, Maris T, Coil D, Wagner T, Wang X, et al.
iScience
. 2021 Sep;
24(9):103017.
PMID: 34522860
The mechanisms by which transcriptional activation domains (tADs) initiate eukaryotic gene expression have been an enigma for decades because most tADs lack specificity in sequence, structure, and interactions with targets....
9.
Evans K, Yuca E, Scott S, Zhao M, Arango N, Cruz Pico C, et al.
Cancer Res
. 2021 Sep;
81(21):5572-5581.
PMID: 34518211
Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top...
10.
Giuliani V, Miller M, Liu C, Hartono S, Class C, Bristow C, et al.
Nat Commun
. 2021 Jul;
12(1):4626.
PMID: 34330913
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that has remained clinically challenging to manage. Here we employ an RNAi-based in vivo functional genomics platform to determine epigenetic vulnerabilities across...