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C Yokoo

Explore the profile of C Yokoo including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 12
Citations 133
Followers 0
Related Specialties
Pharmacology
Infectious Diseases
Biochemistry
Top 10 Co-Authors
M Murata
A Onodera
T Nagate
M Tamai
M Goi
Y Watanabe
K Sota
H Fukushima
K Numata
T Nikawa
Published In
J Antibiot (Tokyo)
Chem Pharm Bull (Tokyo)
FEBS Lett
Xenobiotica
Experientia
Affiliations
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Recent Articles
1.
Aragusterol C: a novel halogenated marine steroid from an Okinawan sponge, Xestospongia sp., possessing potent antitumor activity
Shimura H, Iguchi K, Yamada Y, Nakaike S, Yamagishi T, Matsumoto K, et al.
Experientia . 1994 Feb; 50(2):134-6. PMID: 8125172
A novel chlorinated steroid, aragusterol C, was isolated from an Okinawan marine sponge of the genus Xestospongia. The compound strongly inhibited the proliferation of KB cells in vitro, and also...
2.
Studies on cephalosporin antibiotics. VI. Synthesis, antibacterial activity and oral efficacy in mice of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)-acetamido]-3- (substituted alkylthio)cephalosporins
Yokoo C, Onodera A, Fukushima H, Numata K, Nagate T
J Antibiot (Tokyo) . 1992 Sep; 45(9):1533-9. PMID: 1429240
A series of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido] cephalosporins (1) having various substituted alkylthio groups at the C-3 position of the cephem nucleus were prepared and evaluated for antibacterial activity and oral...
3.
Studies on cephalosporin antibiotics. V. Synthesis, antibacterial activity and oral absorption of new 3-[(Z)-2-methoxycarbonylvinylthio]-7 beta- [(Z)-2-(2-aminothiazol-4-yl)-2-(oxyimino)acetamido]cephalosporins
Yokoo C, Onodera A, Fukushima H, Numata K, Nagate T
J Antibiot (Tokyo) . 1992 Jun; 45(6):932-9. PMID: 1500361
A series of new 3-[(Z)-2-methoxycarbonylvinylthio]-7 beta-[(2- aminothiazol-4-yl)acetamido]-cephalosporins (1) having various oxyimino groups (Z-form) at the alpha position of the C-7 side chain was synthesized and evaluated for antibacterial activity and...
4.
Molecular design of potent inhibitor specific for cathepsin B based on the tertiary structure prediction
Sumiya S, Yoneda T, Kitamura K, Murata M, Yokoo C, Tamai M, et al.
Chem Pharm Bull (Tokyo) . 1992 Feb; 40(2):299-303. PMID: 1606628
To design a potent inhibitor specific for cathepsin B (rat liver), the tertiary structure was predicted based on the crystal structure of the papain complexed with (+)-(2S,3S)-3-(1-[N-(3-methylbutyl)amino]leucylcarbonyl)oxirane-2- carbolylic acid (E-64-c),...
5.
Studies on cephalosporin antibiotics. IV. Synthesis, antibacterial activity and oral absorption of new 3-(2-substituted-vinylthio)-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2- (carboxymethoxyimino)acetamido]cephalosporins
Yokoo C, Goi M, Onodera A, Fukushima H, Nagate T
J Antibiot (Tokyo) . 1991 Dec; 44(12):1422-31. PMID: 1778793
A series of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)ace tamido] cephalosporins (1) having various substituted-vinylthio groups at the C-3 position of the cephen nucleus was synthesized and evaluated for antibacterial activity and oral...
6.
Studies on cephalosporin antibiotics. III. Synthesis, antibacterial activity and oral absorption of new 3-(substituted-alkylthio)-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2- (carboxymethoxyimino)acetamido]cephalosporins
Yokoo C, Goi M, Onodera A, Murata M, Nagate T, Watanabe Y
J Antibiot (Tokyo) . 1991 May; 44(5):498-506. PMID: 2061193
The synthesis, antibacterial activity and oral absorption in rats of new 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)ace tamido] cephalosporins (1) having various substituted-alkylthio groups at the C-3 position of the cephem nucleus are described....
7.
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo
Towatari T, Nikawa T, Murata M, Yokoo C, Tamai M, Hanada K, et al.
FEBS Lett . 1991 Mar; 280(2):311-5. PMID: 2013329
New derivatives of E-64 (compound CA-030 and CA-074) were tested in vitro and in vivo for selective inhibition of cathepsin B. They exhibited 10,000-30,000 times greater inhibitory effects on purified...
8.
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro
Murata M, Miyashita S, Yokoo C, Tamai M, Hanada K, Hatayama K, et al.
FEBS Lett . 1991 Mar; 280(2):307-10. PMID: 2013328
A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these compounds, N-(L-3-trans-ethoxycarbonyloxirane-2-carbonyl)-L-isoleucyl-L-proli ne (compound CA-030) and N-(L-3-trans-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prol ine (compound CA-074)...
9.
Metabolic fate of loxistatin in rat
Fukushima K, Arai M, Tamai M, Yokoo C, Murata M, Suwa T, et al.
Xenobiotica . 1990 Oct; 20(10):1043-51. PMID: 2082594
1. The urinary and plasma metabolites of 14C-loxistatin, a new thiol protease inhibitor, were studied after oral administration to rats. 2. The major metabolites in urine were identified as loxistatin...
10.
Studies on cephalosporin antibiotics. II. Synthesis, antibacterial activity and oral absorption of 3-alkoxycarbonylmethoxy-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)-acetamido]cephalosporins
Yokoo C, Goi M, Onodera A, Murata M, Nagate T, Watanabe Y, et al.
J Antibiot (Tokyo) . 1988 Feb; 41(2):181-92. PMID: 3356606
The synthesis, antibacterial activity and oral absorption in rats of 3-alkoxycarbonyl-methoxy-7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(O-substituted oxyimino)acetamido]cephalosporins (1) are described. In this cephalosporin series, 7 beta-[(Z)-2-(2-aminothiazol-4-yl)-2-(carboxy-methoxyimino)acetamid o] cephalosporins (1b, 1i and 1j) with a...