C W Andrews
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Explore the profile of C W Andrews including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
227
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Recent Articles
1.
Andrews C, Bennett L, Yu L
Pharm Res
. 2000 Aug;
17(6):639-44.
PMID: 10955834
Purpose: The purpose of this investigation was to develop a quantitative structure-bioavailability relationship (QSBR) model for drug discovery and development. Methods: A database of drugs with human oral bioavailability was...
2.
Painter G, Andrews C, Furman P
Nucleosides Nucleotides Nucleic Acids
. 2000 Apr;
19(1-2):13-29.
PMID: 10772700
Nuclear Overhauser effect experiments were used to characterize the protein environment and conformations of dTTP, dATP and AZTTP bound to HIV-RT in the ground state. The results show the initial...
3.
Allen M, Deslauriers M, Andrews C, Tipples G, Walters K, Tyrrell D, et al.
Hepatology
. 1998 Jun;
27(6):1670-7.
PMID: 9620341
Cirrhosis and hepatocellular carcinoma occur as long-term complications of chronic hepatitis B virus (HBV) infection. Antiviral therapy is potentially a successful approach for the treatment of patients with HBV infection,...
4.
Cummins D, Andrews C, Bentley J, Cory M
J Chem Inf Comput Sci
. 1996 Jul;
36(4):750-63.
PMID: 8768767
A molecular descriptor space has been developed which describes structural diversity. Large databases of molecules have been mapped into it and compared. This analysis used five chemical databases, CMC and...
5.
Norman M, Smith H, Andrews C, Tang F, Cowan C, Steffen R
J Med Chem
. 1995 Nov;
38(23):4670-8.
PMID: 7473594
A series of 4-(heteroarylthio)-2-biphenylyltetrazoles was prepared, and the compounds were examined for their ability to displace [3H]AII from angiotensin II receptors. Analogues that exhibited significant receptor binding affinities at less...
6.
Painter G, Aulabaugh A, Andrews C
Biochem Biophys Res Commun
. 1993 Mar;
191(3):1166-71.
PMID: 7682061
Nuclear Overhauser effect experiments were performed at 500 MHz to determine the conformations of AZTTP and dTTP when bound to HIV-1 reverse transcriptase. The conformations of both ligands were found...
7.
Bair K, Andrews C, TUTTLE R, Knick V, Cory M, McKee D
J Med Chem
. 1991 Jul;
34(7):1983-90.
PMID: 2066971
The effects of variation of aromatic ring size, shape, and side-chain position on antitumor activity and DNA binding in a series of carbocyclic 2-[(arylmethyl)amino]-2-methyl-1,3-propanediols (AMAPs) were examined. In general, the...
8.
Besterman J, ELWELL L, Cragoe Jr E, Andrews C, Cory M
J Biol Chem
. 1989 Feb;
264(4):2324-30.
PMID: 2536704
Among its many properties, amiloride is a DNA intercalator and topoisomerase II inhibitor. Previous work has indicated that the most stable conformation for amiloride is a planar, hydrogen-bonded, tricyclic structure....
9.
INSULL Jr W, Hata Y, Meakin J, Marchant L, Andrews C, Buzek B
Atherosclerosis
. 1974 May;
19(3):555-60.
PMID: 4828573
No abstract available.
10.