C Srinivasan
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Explore the profile of C Srinivasan including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
337
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Recent Articles
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Wei J, Srinivasan C, Han H, Valentine J, Gralla E
J Biol Chem
. 2001 Oct;
276(48):44798-803.
PMID: 11581253
The LYS7 gene in Saccharomyces cerevisiae encodes a protein (yCCS) that delivers copper to the active site of copper-zinc superoxide dismutase (CuZn-SOD, a product of the SOD1 gene). In yeast...
13.
Minadeo N, Layden B, Amari L, Thomas V, Radloff K, Srinivasan C, et al.
Arch Biochem Biophys
. 2001 May;
388(1):7-12.
PMID: 11361143
Although lithium salts have been used in the treatment and prophylaxis of manic-depressive or bipolar patients for 50 years, the mechanism of the pharmacologic action of Li+ is unknown. Based...
14.
Srinivasan C, Williams W, Nagasawa H, Chen T
Biochem Pharmacol
. 2001 Mar;
61(7):925-31.
PMID: 11274980
The cysteine (Cys) precursor 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid (PTCA) has been shown to protect against acetaminophen (APAP)-induced hepatic GSH, GSSG, and Cys depletion and hepatic necrosis. The aim of this study was...
15.
Srinivasan C, Williams W, Ray M, Chen T
Biochem Pharmacol
. 2001 Feb;
61(2):245-52.
PMID: 11163339
The cysteine (Cys) precursor 2(R,S)-n-propylthiazolidine-4(R)-carboxylic acid (PTCA) was shown previously to maintain near normal levels of hepatic GSH and GSSG at 24 hr and to protect against hepatic necrosis and...
16.
Heaton D, Nittis T, Srinivasan C, Winge D
J Biol Chem
. 2000 Sep;
275(48):37582-7.
PMID: 10970896
The copper metallochaperone Cox17 is proposed to shuttle Cu(I) ions to the mitochondrion for the assembly of cytochrome c oxidase. The Cu(I) ions are liganded by cysteinyl thiolates. Mutational analysis...
17.
Bird A, Zhao H, Luo H, Jensen L, Srinivasan C, Winge D, et al.
EMBO J
. 2000 Jul;
19(14):3704-13.
PMID: 10899124
The Zap1 transcriptional activator of Saccharomyces cerevisiae controls zinc homeostasis. Zap1 induces target gene expression in zinc-limited cells and is repressed by high zinc. One such target gene is ZAP1...
18.
Srinivasan C, Liba A, Imlay J, Valentine J, Gralla E
J Biol Chem
. 2000 Jul;
275(38):29187-92.
PMID: 10882731
A current hypothesis explaining the toxicity of superoxide anion in vivo is that it oxidizes exposed [4Fe-4S] clusters in certain vulnerable enzymes causing release of iron and enzyme inactivation. The...
19.
Srinivasan C, Minadeo N, Geraldes C, Mota de Freitas D
Lipids
. 1999 Dec;
34(11):1211-21.
PMID: 10606045
The mode of action of the lithium ion (Li+) in the treatment of manic depression or bipolar illness is still under investigation, although this inorganic drug has been in clinical...
20.
Jamison McDaniels C, Jensen L, Srinivasan C, Winge D, Tullius T
J Biol Chem
. 1999 Sep;
274(38):26962-7.
PMID: 10480908
Mac1 is a metalloregulatory protein that regulates expression of the high affinity copper transport system in the yeast Saccharomyces cerevisiae. Under conditions of high copper concentration, Mac1 represses transcription of...