C Slingsby
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Explore the profile of C Slingsby including associated specialties, affiliations and a list of published articles.
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75
Citations
1800
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Recent Articles
1.
Clark A, Naylor C, Bagneris C, Keep N, Slingsby C
J Mol Biol
. 2011 Feb;
408(1):118-34.
PMID: 21329698
Small heat shock proteins form large cytosolic assemblies from an "α-crystallin domain" (ACD) flanked by sequence extensions. Mutation of a conserved arginine in the ACD of several human small heat...
2.
Bagneris C, Bateman O, Naylor C, Cronin N, Boelens W, Keep N, et al.
J Mol Biol
. 2009 Aug;
392(5):1242-52.
PMID: 19646995
Small heat shock proteins (sHsps) are a family of large and dynamic oligomers highly expressed in long-lived cells of muscle, lens and brain. Several family members are upregulated during stress,...
3.
Evans P, Bateman O, Slingsby C, Wallace B
Exp Eye Res
. 2007 Apr;
84(5):1001-8.
PMID: 17400211
Circular dichroism (CD) spectroscopy is a powerful solution technique for the study of protein secondary structure. As hierarchical euclidean clustering analyses of high quality crystallin synchrotron radiation circular dichroism (SRCD)...
4.
Evans P, Wyatt K, Wistow G, Bateman O, Wallace B, Slingsby C
J Mol Biol
. 2004 Sep;
343(2):435-44.
PMID: 15451671
Mutations in the human gammaD-crystallin gene have been linked to several types of congenital cataracts. In particular, the Pro23 to Thr (P23T) mutation of human gammaD crystallin has been linked...
5.
Reddy M, Bateman O, Chakarova C, Ferris J, Berry V, Lomas E, et al.
Hum Mol Genet
. 2004 Mar;
13(9):945-53.
PMID: 15016766
Congenital cataract is a leading cause of visual disability in children. Inherited isolated (non-syndromic) cataract represents a significant proportion of cases and the identification of genes responsible for inherited cataract...
6.
Bateman O, Sarra R, van Genesen S, KAPPE G, Lubsen N, Slingsby C
Exp Eye Res
. 2003 Sep;
77(4):409-22.
PMID: 12957141
Crystallins are bulk structural proteins of the eye lens that have to last a life time. They gradually become modified with age, denature and form light scattering centres. High thermodynamic...
7.
Bateman O, Purkiss A, van Montfort R, Slingsby C, Graham C, Wistow G
Biochemistry
. 2003 Apr;
42(15):4349-56.
PMID: 12693930
Eta-crystallin is a retinal dehydrogenase that has acquired a role as a structural protein in the eye lens of elephant shrews, members of an ancient order of mammals. While it...
8.
Nandrot E, Slingsby C, Basak A, Cherif-Chefchaouni M, Benazzouz B, Hajaji Y, et al.
J Med Genet
. 2003 Apr;
40(4):262-7.
PMID: 12676897
Congenital cataracts are a major cause of bilateral visual impairment in childhood. We mapped the gene responsible for autosomal congenital cerulean cataracts to chromosome 2q33-35 in a four generation family...
9.
van Montfort R, Slingsby C, Vierling E
Adv Protein Chem
. 2002 Mar;
59:105-56.
PMID: 11868270
No abstract available.
10.
Jaenicke R, Slingsby C
Crit Rev Biochem Mol Biol
. 2001 Nov;
36(5):435-99.
PMID: 11724156
abg-Crystallins are the major protein components in the vertebrate eye lens--a as a molecular chaperone and b and g as structural proteins. Surprisingly, the latter two share some structural characteristics...