C S McLean
Overview
Explore the profile of C S McLean including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
276
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Recent Articles
1.
Loudon P, Blakeley D, Boursnell M, Day D, Duncan I, Lowden R, et al.
J Gene Med
. 2001 Oct;
3(5):458-67.
PMID: 11601759
Background: DISC-hGMCSF is a gH-deleted HSV-2 based vector expressing human GM-CSF that is being developed for cancer immunotherapy. To support first clinical use, a range of preclinical safety studies were...
2.
Ali S, McLean C, Boursnell M, Martin G, HOLMES C, Reeder S, et al.
Cancer Res
. 2000 Apr;
60(6):1663-70.
PMID: 10749137
The development of genetically modified "whole" tumor cell vaccines for cancer therapy relies on the efficient transduction and expression of genes by vectors. In the present study, we have used...
3.
Disabled infectious single cycle (DISC) herpes simplex virus as a vector for immunotherapy of cancer
Boursnell M, Entwisle C, Ali S, Sivasubramaniam S, Reeder S, McLean C, et al.
Adv Exp Med Biol
. 1999 Feb;
451:379-84.
PMID: 10026900
No abstract available.
4.
Boursnell M, Entwisle C, Blakeley D, Roberts C, Duncan I, Chisholm S, et al.
J Infect Dis
. 1997 Jan;
175(1):16-25.
PMID: 8985191
A glycoprotein H (gH)-deleted herpes simplex virus type 2 (HSV-2) was evaluated as a vaccine for the prevention of HSV-induced disease. This virus, which we term a DISC (disabled infectious...
5.
Boursnell M, Rutherford E, Hickling J, Rollinson E, Munro A, Rolley N, et al.
Vaccine
. 1996 Nov;
14(16):1485-94.
PMID: 9014288
The presence and consistent expression of the genes encoding the human papillomavirus (HPV) E6 and E7 proteins in the great majority of cervical tumours presents the opportunity for an immunotherapeutic...
6.
McLean C, Ni Challanain D, Duncan I, Boursnell M, Jennings R, Inglis S
Vaccine
. 1996 Jul;
14(10):987-92.
PMID: 8873393
The vaccine potential of a genetically disabled Herpes Simplex Virus Type 1 virus (DISC HSV-1) was investigated in the guinea pig model of intravaginal (i.vag.) HSV-2 infection. Three mucosal vaccination...
7.
McLean C, Erturk M, Jennings R, Challanain D, Minson A, Duncan I, et al.
J Infect Dis
. 1994 Nov;
170(5):1100-9.
PMID: 7963701
The vaccine potential of a mutant herpes simplex virus (HSV) type 1, with a deletion in the glycoprotein H (gH) gene, was evaluated. The virus requires a gH-expressing cell line...
8.
Farrell H, McLean C, Harley C, Efstathiou S, Inglis S, Minson A
J Virol
. 1994 Feb;
68(2):927-32.
PMID: 8289395
Several approaches to the production of vaccines to human herpesviruses have been proposed. Subunit vaccines, subunits delivered by live vectors, and rationally attenuated vaccines have all been shown to be...
9.
McLean C, Sterling J, Mowat J, Nash A, Stanley M
J Gen Virol
. 1993 Feb;
74 ( Pt 2):239-45.
PMID: 8381463
To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto...
10.
Cromer B, McLean C, HEALD F
J Adolesc Health
. 1992 Mar;
13(2 Suppl):1S-65S.
PMID: 1606168
No abstract available.