C S Leonard
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Explore the profile of C S Leonard including associated specialties, affiliations and a list of published articles.
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31
Citations
939
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Recent Articles
1.
Kukkonen J, Leonard C
Br J Pharmacol
. 2013 Aug;
171(2):314-31.
PMID: 23902572
Orexin (hypocretin) peptides and their two known G-protein-coupled receptors play essential roles in sleep-wake control and powerfully influence other systems regulating appetite/metabolism, stress and reward. Consequently, drugs that influence signalling...
2.
Leonard C, Kukkonen J
Br J Pharmacol
. 2013 Jul;
171(2):294-313.
PMID: 23848055
Multiple homeostatic systems are regulated by orexin (hypocretin) peptides and their two known GPCRs. Activation of orexin receptors promotes waking and is essential for expression of normal sleep and waking...
3.
Kalogiannis M, Grupke S, Potter P, Edwards J, Chemelli R, Kisanuki Y, et al.
Eur J Neurosci
. 2010 Jun;
32(1):130-42.
PMID: 20576035
Pharmacological studies of narcoleptic canines indicate that exaggerated pontine cholinergic transmission promotes cataplexy. As disruption of orexin (hypocretin) signaling is a primary defect in narcolepsy with cataplexy, we investigated whether...
4.
5.
Kohlmeier K, Watanabe S, Tyler C, Burlet S, Leonard C
J Neurophysiol
. 2008 Aug;
100(4):2265-81.
PMID: 18667550
The hypocretin/orexins (Hcrt/Orxs) are hypothalamic neuropeptides that regulate stress, addiction, feeding, and arousal behaviors. They depolarize many types of central neurons and can increase [Ca2+]i in some, including those of...
6.
Leonard C, Michaelis E, Mitchell K
J Neurophysiol
. 2001 Nov;
86(5):2159-72.
PMID: 11698508
The behavioral-state related firing of mesopontine cholinergic neurons of the laterodorsal tegmental nucleus appears pivotal for generating both arousal and rapid-eye-movement sleep. Since these neurons express high levels of nitric...
7.
Lau D, Contreras D, Ozaita A, Harvey M, Chow A, Noebels J, et al.
J Neurosci
. 2000 Dec;
20(24):9071-85.
PMID: 11124984
Voltage-gated K(+) channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to -10 mV) and very fast deactivation rates, suggesting special roles in...
8.
Leonard C, Rao S, Inoue T
J Neurophysiol
. 2000 Sep;
84(3):1558-72.
PMID: 10980027
Nitric oxide synthase (NOS)-containing mesopontine cholinergic (MPCh) neurons of the laterodorsal tegmental nucleus (LDT) are hypothesized to drive the behavioral states of waking and REM sleep through a tonic increase...
9.
Erisir A, Lau D, Rudy B, Leonard C
J Neurophysiol
. 1999 Nov;
82(5):2476-89.
PMID: 10561420
Fast-spiking GABAergic interneurons of the neocortex and hippocampus fire high-frequency trains of brief action potentials with little spike-frequency adaptation. How these striking properties arise is unclear, although recent evidence suggests...
10.
Surkis A, Peskin C, Tranchina D, Leonard C
J Neurophysiol
. 1998 Nov;
80(5):2593-607.
PMID: 9819266
The laterodorsal tegmental nucleus (LDT) is located in the dorsolateral pontine reticular formation. Cholinergic neurons in the LDT and the adjacent pedunculopontine tegmental nucleus (PPT) are hypothesized to play a...