C S Hughes
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Explore the profile of C S Hughes including associated specialties, affiliations and a list of published articles.
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35
Citations
265
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Recent Articles
1.
Hughes C, Longo E, Phillips-Jones M, Hussain R
Data Brief
. 2017 Aug;
14:41-47.
PMID: 28765830
This data article presents the results from quality control experiments including N-terminal sequencing, SEC-MALS and Mass Spectrometry for purified VanS used in experiments described in (Hughes et al., 2017) [1];...
2.
Hughes C, Longo E, Phillips-Jones M, Hussain R
Biochim Biophys Acta Gen Subj
. 2017 May;
1861(8):1951-1959.
PMID: 28511809
A-type resistance towards "last-line" glycopeptide antibiotic vancomycin in the leading hospital acquired infectious agent, the enterococci, is the most common in the UK. Resistance is regulated by the VanRS two-component...
3.
Hughes C, Patek S, Breton M, Kovatchev B
Comput Methods Programs Biomed
. 2010 Jul;
102(2):138-48.
PMID: 20646777
Automatic control of Type 1 Diabetes Mellitus (T1DM) with subcutaneous (SC) measurement of glucose concentration and subcutaneous (SC) insulin infusion is of great interest within the diabetes technology research community....
4.
Page R, Hughes C, Huyan S, Sagris J, Trogdon M
Anticancer Res
. 2000 Dec;
20(5B):3533-8.
PMID: 11131658
Objective: To characterize the chemosensitivity of wild type and multidrug resistant canine cell lines and determine the relative potency of the P-glycoprotein (Pgp) modulators verapamil, tamoxifen and a cyclosporin-A analog...
5.
Steingold S, Sharp N, McGahan M, Hughes C, Dunn S, Page R
Anticancer Res
. 1998 May;
18(1A):393-400.
PMID: 9568108
Background: Overexpression of the MDR1 gene often contributes to antineoplastic drug resistance. The purpose of this study was to characterize the canine MDR1 mRNA homologue and evaluate its expression in...
6.
Hughes C, Vaden S, Manaugh C, Price G, Hudson L
J Neurooncol
. 1998 Apr;
37(1):45-54.
PMID: 9525837
P-glycoprotein (Pgp) is an inducible transmembrane protein that functions as an ATP-dependent efflux pump. Pgp is normally expressed in two types of cells: specialized epithelial cells with secretory/excretory functions (e.g.,...
7.
Lindberg R, Dewhirst M, Buckley B, Hughes C, Whorton A
Am J Physiol
. 1996 Jul;
271(1 Pt 1):C332-7.
PMID: 8760062
We have characterized the ability of several cell types associated with the microvasculature of solid tumors to release nitric oxide (NO.) in response to increases in cytosolic Ca2+ concentration ([Ca2+]c)....
8.
P-glycoprotein expression in canine lymphoma: a relevant, intermediate model of multidrug resistance
Lee J, Hughes C, Fine R, Page R
Cancer
. 1996 May;
77(9):1892-8.
PMID: 8646690
Background: Despite extensive investigation, the role of MDR of human cancer remains unclear. Canine lymphoma is a spontaneously arising correlate of human non-Hodgkin's lymphoma that may complement other in vivo...
9.
Dunn S, Hughes C, Leblanc G, Cullen J
Hepatology
. 1996 Apr;
23(4):662-8.
PMID: 8666315
The leading cause of human hepatocellular carcinomas (HCCs) is hepatitis B virus (HBV) infection. Woodchucks infected with a closely related hepadnavirus, woodchuck hepatitis virus (WHV), serve as a model for...
10.
Hudson L, Hughes C, Vaden S
Lab Anim Sci
. 1994 Aug;
44(4):358-61.
PMID: 7983848
Modification of a previously published technique for cerebrospinal fluid collection in rats is described. This technique uses general anesthesia, a supporting platform to flex the head-neck junction, a surgical approach...