C Rommel
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Explore the profile of C Rommel including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
1301
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Recent Articles
1.
Janes M, Vu C, Mallya S, Shieh M, Limon J, Li L, et al.
Leukemia
. 2012 Oct;
27(3):586-94.
PMID: 23090679
The mechanistic target of rapamycin (mTOR) is a serine/threonine kinase whose activity contributes to leukemia proliferation and survival. Compounds targeting the mTOR active site inhibit rapamycin-resistant functions and have enhanced...
2.
Billottet C, Grandage V, Gale R, Quattropani A, Rommel C, Vanhaesebroeck B, et al.
Oncogene
. 2006 May;
25(50):6648-59.
PMID: 16702948
Current therapy for acute myeloid leukaemia (AML) is suboptimal with a high incidence of relapse. There is strong evidence that constitutive phosphoinositide 3-kinase (PI3K) activity plays a significant role in...
3.
Johnson Z, Power C, Weiss C, RINTELEN F, Ji H, Ruckle T, et al.
Biochem Soc Trans
. 2004 Mar;
32(Pt 2):366-77.
PMID: 15046611
Chemokines are small chemoattractant cytokines that control a wide variety of biological and pathological processes, ranging from immunosurveillance to inflammation, and from viral infection to cancer. Genetic and pharmacological studies...
4.
Rommel C, Bodine S, Clarke B, Rossman R, Nunez L, Stitt T, et al.
Nat Cell Biol
. 2001 Nov;
3(11):1009-13.
PMID: 11715022
Skeletal muscle is composed of multinucleated fibres, formed after the differentiation and fusion of myoblast precursors. Skeletal muscle atrophy and hypertrophy refer to changes in the diameter of these pre-existing...
5.
Halfar K, Rommel C, Stocker H, Hafen E
Development
. 2001 Apr;
128(9):1687-96.
PMID: 11290305
Ras mediates a plethora of cellular functions during development. In the developing eye of Drosophila, Ras performs three temporally separate functions. In dividing cells, it is required for growth but...
6.
Heinicke T, Radziwill G, Nawrath M, Rommel C, Pavlovic J, Moelling K
Cancer Gene Ther
. 2000 Jun;
7(5):697-706.
PMID: 10830717
Activating mutants of ras are among the most frequently found genetic alterations in human cancers. Therefore, Ras appears to be an attractive target for therapeutic intervention using gene transfer. The...
7.
Rommel C, Clarke B, Zimmermann S, Nunez L, Rossman R, Reid K, et al.
Science
. 1999 Nov;
286(5445):1738-41.
PMID: 10576741
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK is mitogen-activated protein kinase or ERK kinase, and PI3K is...
8.
Kleinbohl D, Holzl R, Moltner A, Rommel C, Weber C, Osswald P
Pain
. 1999 Jun;
81(1-2):35-43.
PMID: 10353491
Sensitization to continued nociceptive stimulation is supposed to be involved in the development of chronic pain at several levels of the CNS, but experimental studies investigating the perceptual dynamics of...
9.
Rommel C, Hafen E
Curr Opin Genet Dev
. 1998 Sep;
8(4):412-8.
PMID: 9729716
With the number of known roles played by Ras proteins increasing rapidly, finding answers to how the diverse cellular responses are triggered is becoming increasingly pertinent. Although our understanding of...
10.
Dubois T, Rommel C, Howell S, Steinhussen U, Soneji Y, Morrice N, et al.
J Biol Chem
. 1997 Nov;
272(46):28882-8.
PMID: 9360956
14-3-3 proteins mediate interactions between proteins involved in signal transduction and cell cycle regulation. Phosphorylation of target proteins as well as 14-3-3 are important for protein-protein interactions. Here, we describe...