C R Elzinga
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Explore the profile of C R Elzinga including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
192
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Recent Articles
1.
de Vries B, Meurs H, Roffel A, Elzinga C, Hoiting B, de Vries M, et al.
Br J Pharmacol
. 2000 Oct;
131(5):915-20.
PMID: 11053211
According to the two state receptor model, the beta(2)-adrenergic receptor (beta(2)-AR) isomerizes between an inactive state and a constitutively active state, which couples to the stimulatory G-protein in the absence...
2.
Mak J, Roffel A, Katsunuma T, Elzinga C, Zaagsma J, Barnes P
Mol Pharmacol
. 2000 Apr;
57(5):857-64.
PMID: 10779367
Histamine, released from activated mast cells, causes bronchoconstriction mediated by H(1) receptors, whereas beta(2)-agonists are widely used for the relief of bronchoconstriction. In this study, we examined the effects of...
3.
Katsunuma T, Roffel A, Elzinga C, Zaagsma J, Barnes P, Mak J
Am J Respir Cell Mol Biol
. 1999 Aug;
21(3):409-17.
PMID: 10460759
Neurokinin A (NKA) induces bronchoconstriction mediated by tachykinin NK(2) receptors in animals and humans, and may be increased in asthma. Because beta(2)-adrenoceptor agonists are the most widely used bronchodilators in...
4.
Roffel A, Davids J, Elzinga C, Wolf D, Zaagsma J, Kilbinger H
Br J Pharmacol
. 1997 Sep;
122(1):133-41.
PMID: 9298539
1. The muscarinic receptor subtypes mediating contraction of the guinea-pig lung strip and inhibition of the release of acetylcholine from cholinergic vagus nerve endings in the guinea-pig trachea in vitro...
5.
Hoiting B, Meurs H, Schuiling M, Kuipers R, Elzinga C, Zaagsma J
Br J Pharmacol
. 1996 Feb;
117(3):419-426.
PMID: 8821529
1. The effects of increased cellular cyclic AMP levels induced by isoprenaline, forskolin and 8-bromoadenosine 3':5'-cyclic monophosphate (8-Br-cyclic AMP) on phosphoinositide metabolism and changes in intracellular Ca2+ elicited by methacholine...
6.
Hoiting B, Kuipers R, Elzinga C, Zaagsma J, Meurs H
Eur J Pharmacol
. 1995 Jul;
290(2):R5-7.
PMID: 8575523
In isolated bovine tracheal smooth muscle cells, the potent and specific protein kinase C inhibitor GF 109203X caused an inhibition of methacholine-and histamine-induced Ca2+ mobilization and influx, indicating for the...
7.
Roffel A, Meurs H, Elzinga C, Zaagsma J
Br J Pharmacol
. 1995 Jun;
115(4):665-71.
PMID: 7582488
1. The functional antagonism between methacholine- or histamine-induced contraction and beta-adrenoceptor-mediated relaxation was evaluated in bovine tracheal smooth muscle in vitro. In addition, the putative contribution of muscarinic M2 receptors...
8.
Selectivity profile of some recent muscarinic antagonists in bovine and guinea-pig trachea and heart
Roffel A, Hamstra J, Elzinga C, Zaagsma J
Arch Int Pharmacodyn Ther
. 1994 Jul;
328(1):82-98.
PMID: 7893193
The functional affinities of some recently developed subtype-selective muscarinic antagonists towards bovine tracheal smooth muscle muscarinic M3 receptors were established and compared to binding affinities for bovine cardiac M2 and...
9.
Roffel A, Elzinga C, Zaagsma J
Eur J Pharmacol
. 1993 Dec;
250(2):267-79.
PMID: 8112384
The muscarinic receptor subtype mediating contraction of the guinea pig lung strip preparation was investigated and compared with that in guinea pig tracheal and human peripheral airway (small bronchi) smooth...
10.
Roffel A, Meurs H, Elzinga C, Zaagsma J
Eur J Pharmacol
. 1993 Nov;
249(2):235-8.
PMID: 8287906
We investigated whether muscarinic M2 receptors, known to inhibit adenylyl cyclase activity in airway smooth muscle, also inhibit isoprenaline-induced relaxation of guinea pig tracheal smooth muscle, as has recently been...