C R Dearolf
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Explore the profile of C R Dearolf including associated specialties, affiliations and a list of published articles.
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20
Citations
792
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Recent Articles
1.
Luo H, Rose P, Roberts T, Dearolf C
Mol Genet Genomics
. 2002 Mar;
267(1):57-63.
PMID: 11919715
Cytokines regulate the development and differentiated functions of hematopoietic cells by activating multiple signaling pathways, including the Jak-Stat pathway, the PI3-kinase pathway, and the Ras/Raf pathway. While the Jak-Stat interaction...
2.
Luo H, Dearolf C
Bioessays
. 2001 Dec;
23(12):1138-47.
PMID: 11746233
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila....
3.
Bentley A, Maclennan B, Calvo J, Dearolf C
Genetics
. 2000 Nov;
156(3):1169-73.
PMID: 11063692
Reverse genetic techniques will be necessary to take full advantage of the genomic sequence data for Drosophila and other experimental organisms. To develop a method for the targeted recovery of...
4.
Myrick K, Dearolf C
Gene
. 2000 Feb;
244(1-2):119-25.
PMID: 10689194
Jak kinase-Stat protein pathways play a critical role in the response of blood cells to a range of cytokines and growth factors. We are using the fruit fly, Drosophila melanogaster,...
5.
Dearolf C
Cell Mol Life Sci
. 1999 Oct;
55(12):1578-84.
PMID: 10526575
Invertebrate organisms provide systems to elucidate the developmental roles of Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathways, thereby complementing research conducted with mammalian cells and animals....
6.
Luo H, Asha H, Kockel L, Parke T, Mlodzik M, Dearolf C
Dev Biol
. 1999 Sep;
213(2):432-41.
PMID: 10479459
Jak kinases are critical signaling components in hematopoiesis. While a large number of studies have been conducted on the roles of Jak kinases in the hematopoietic cells, much less is...
7.
8.
Yasothornsrikul S, Davis W, Cramer G, Kimbrell D, Dearolf C
Gene
. 1997 Nov;
198(1-2):17-25.
PMID: 9370260
We have taken an enhancer trap approach to identify genes that are expressed in hematopoietic cells and tissues of Drosophila. We conducted a molecular analysis of two P-element insertion strains...
9.
Luo H, Rose P, Barber D, Hanratty W, Lee S, Roberts T, et al.
Mol Cell Biol
. 1997 Mar;
17(3):1562-71.
PMID: 9032284
The Jak (Janus) family of nonreceptor tyrosine kinases plays a critical role in cytokine signal transduction pathways. In Drosophila melanogaster, the dominant hop(Tum-l) mutation in the Hop Jak kinase causes...
10.
Yan R, Luo H, Darnell Jr J, Dearolf C
Proc Natl Acad Sci U S A
. 1996 Jun;
93(12):5842-7.
PMID: 8650180
We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site mutations that suppress the phenotype of the hyperactive hopTum-1 Jak kinase,...