C R Bertozzi
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Explore the profile of C R Bertozzi including associated specialties, affiliations and a list of published articles.
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46
Citations
2168
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Recent Articles
1.
Armstrong J, Bertozzi C
Curr Opin Drug Discov Devel
. 2009 Aug;
3(5):502-15.
PMID: 19649879
Sulfated biomolecules regulate a diverse array of normal and pathological cellular communication events. The participation of these bioconjugates in a variety of disease states has sparked interest in the enzyme...
2.
Grossman H, MYERS W, Vreeland V, Bruehl R, Alper M, Bertozzi C, et al.
Proc Natl Acad Sci U S A
. 2003 Dec;
101(1):129-34.
PMID: 14688406
We demonstrate a technique for detecting magnetically labeled Listeria monocytogenes and for measuring the binding rate between antibody-linked magnetic particles and bacteria. This sensitive assay quantifies specific bacteria in a...
3.
Nauman D, Bertozzi C
Biochim Biophys Acta
. 2001 Dec;
1568(2):147-54.
PMID: 11750762
Human cells incubated with N-levulinoylmannosamine (ManLev) process this unnatural metabolic precursor into N-levulinoyl sialic acid (SiaLev), which is incorporated into cell surface glycoconjugates. A key feature of SiaLev is the...
4.
Marcaurelle L, Shin Y, Goon S, Bertozzi C
Org Lett
. 2001 Nov;
3(23):3691-4.
PMID: 11700114
[reaction--see text] The synthesis of oxime-linked mucin mimics was accomplished via the incorporation of multiple ketone residues into a peptide followed by reaction with aminooxy sugars corresponding to the tumor-related...
5.
Sampson N, Mrksich M, Bertozzi C
Proc Natl Acad Sci U S A
. 2001 Nov;
98(23):12870-1.
PMID: 11687628
The spatial display of cellular ligands and receptors is important for cell adhesion and communication. Two approaches that emphasize developing selective methods to dissect, modify, and control receptor-ligand interactions at...
6.
SAXON E, Bertozzi C
Annu Rev Cell Dev Biol
. 2001 Nov;
17:1-23.
PMID: 11687482
Oligosaccharides play a crucial role in many of the recognition, signaling, and adhesion events that take place at the surface of cells. Abnormalities in the synthesis or presentation of these...
7.
Jacobs C, Goon S, Yarema K, Hinderlich S, Hang H, Chai D, et al.
Biochemistry
. 2001 Oct;
40(43):12864-74.
PMID: 11669623
Unnatural analogues of sialic acid can be delivered to mammalian cell surfaces through the metabolic transformation of unnatural N-acetylmannosamine (ManNAc) derivatives. In previous studies, mannosamine analogues bearing simple N-acyl groups...
8.
Schilling B, Goon S, Samuels N, Gaucher S, Leary J, Bertozzi C, et al.
Biochemistry
. 2001 Oct;
40(42):12666-77.
PMID: 11601991
Haemophilus ducreyi is a Gram-negative bacterium that causes chancroid, a sexually transmitted disease. Cell surface lipooligosaccharides (LOS) of H. ducreyi are thought to play important biological roles in host infection....
9.
Mahal L, Charter N, Angata K, Fukuda M, Koshland Jr D, Bertozzi C
Science
. 2001 Oct;
294(5541):380-1.
PMID: 11598302
Poly-alpha2,8-sialic acid (PSA) has been implicated in numerous normal and pathological processes, including development, neuronal plasticity, and tumor metastasis. We report that cell surface PSA expression can be reversibly inhibited...
10.
Hang H, Bertozzi C
Acc Chem Res
. 2001 Sep;
34(9):727-36.
PMID: 11560472
Oligosaccharides on proteins and lipids play central roles in human health and disease. The molecular analysis of glycoconjugate function has benefited tremendously from new methods for their chemical synthesis, which...