C Peter Downes
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Explore the profile of C Peter Downes including associated specialties, affiliations and a list of published articles.
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40
Citations
2741
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Recent Articles
1.
IQGAP proteins reveal an atypical phosphoinositide (aPI) binding domain with a pseudo C2 domain fold
Dixon M, Gray A, Schenning M, Agacan M, Tempel W, Tong Y, et al.
J Biol Chem
. 2012 Apr;
287(27):22483-96.
PMID: 22493426
Class I phosphoinositide (PI) 3-kinases act through effector proteins whose 3-PI selectivity is mediated by a limited repertoire of structurally defined, lipid recognition domains. We describe here the lipid preferences...
2.
Dixon M, Gray A, Boisvert F, Agacan M, Morrice N, Gourlay R, et al.
Mol Cell Proteomics
. 2011 Jan;
10(4):M110.003178.
PMID: 21263009
Class I phosphoinositide 3-kinases exert important cellular effects through their two primary lipid products, phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P(2)). As few molecular targets for PtdIns(3,4)P(2) have yet been identified,...
3.
Maccario H, Perera N, Gray A, Downes C, Leslie N
J Biol Chem
. 2010 Feb;
285(17):12620-8.
PMID: 20177066
The PTEN (phosphatase and tensin homolog) tumor suppressor is a phosphatase that inhibits phosphoinositide 3-kinase-dependent signaling by metabolizing the phosphoinositide lipid phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)) at the plasma membrane. PTEN can...
4.
Leslie N, Spinelli L, Tibarewal P, Zilidis G, Weerasinghe N, Lim J, et al.
Adv Enzyme Regul
. 2009 Nov;
50(1):112-8.
PMID: 19895830
No abstract available.
5.
van Diepen M, Parsons M, Downes C, Leslie N, Hindges R, Eickholt B
Nat Cell Biol
. 2009 Sep;
11(10):1191-6.
PMID: 19767745
The tumour suppressor PTEN can inhibit cell proliferation and migration as well as control cell growth, in different cell types. PTEN functions predominately as a lipid phosphatase, converting PtdIns(3,4,5)P(3) to...
6.
Padmanabhan U, Dollins D, Fridy P, York J, Downes C
J Biol Chem
. 2009 Feb;
284(16):10571-82.
PMID: 19208622
Inositol hexakisphosphate kinases (IP6Ks) phosphorylate inositol hexakisphosphate (InsP(6)) to yield 5-diphosphoinositol pentakisphosphate (5-[PP]-InsP(5) or InsP(7)). In this study, we report the characterization of a selective inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine (TNP), for...
7.
Hale B, Batty I, Downes C, Randall R
J Biol Chem
. 2007 Nov;
283(3):1372-1380.
PMID: 18029356
Influenza A virus NS1 protein stimulates host-cell phosphoinositide 3-kinase (PI3K) signaling by binding to the p85beta regulatory subunit of PI3K. Here, in an attempt to establish a mechanism for this...
8.
Batty I, van der Kaay J, Gray A, Telfer J, Dixon M, Downes C
Biochem J
. 2007 Aug;
407(2):255-66.
PMID: 17672824
Activation of class Ia PI3K (phosphoinositide 3-kinase) produces PtdInsP3, a vital intracellular mediator whose degradation generates additional lipid signals. In the present study vanadate analogues that inhibit PTPs (protein tyrosine...
9.
Maccario H, Perera N, Davidson L, Downes C, Leslie N
Biochem J
. 2007 Apr;
405(3):439-44.
PMID: 17444818
Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of...
10.
Ross S, Lindsay Y, Safrany S, Lorenzo O, Villa F, Toth R, et al.
Cell Signal
. 2007 Mar;
19(7):1521-30.
PMID: 17346927
The Protein Tyrosine Phosphatase (PTP) family comprises a large and diverse group of enzymes, regulating a range of biological processes through de-phosphorylation of many proteins and lipids. These enzymes share...