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C Nordstedt

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Articles 51
Citations 1358
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Recent Articles
1.
Gandy S, Naslund J, Nordstedt C
Nature . 2001 Jun; 411(6838):654-6. PMID: 11395757
Alzheimer's disease is characterized by accumulation in the brain of a family of insoluble amyloid peptides (Abeta peptides), which are produced as a result of the normal processing of beta-amyloid...
2.
Lannfelt L, Nordstedt C
J Neural Transm Suppl . 2000 Aug; 59:155-61. PMID: 10961427
Considerable advances have been made the last years in the understanding of the pathogenesis of Alzheimer's disease (AD): Several pathogenic mutations have been found in the amyloid precursor protein gene...
3.
Jensen M, Hartmann T, Engvall B, Wang R, Uljon S, Sennvik K, et al.
Mol Med . 2000 Aug; 6(4):291-302. PMID: 10949910
Background: The amyloid beta (Abeta) peptide is a key molecule in the pathogenesis of Alzheimer's disease. Reliable methods to detect and quantify soluble forms of this peptide in human biological...
4.
Bohrmann B, Adrian M, Dubochet J, Kuner P, Muller F, Huber W, et al.
J Struct Biol . 2000 Aug; 130(2-3):232-46. PMID: 10940228
Assemblyof the amyloid-beta peptide (Abeta) into fibrils and its deposition in distinct brain areas is considered responsible for the pathogenesis of Alzheimer's disease (AD). Thus, inhibition of fibril assembly is...
5.
Kuner P, Bohrmann B, Tjernberg L, Naslund J, Huber G, Celenk S, et al.
J Biol Chem . 2000 Jan; 275(3):1673-8. PMID: 10636861
The Alzheimer beta-amyloid peptide (Abeta) and a fragment of the prion protein have the capacity of forming amyloid-like fibrils when incubated under physiological conditions in vitro. Here we show that...
6.
Hilfiker S, Pieribone V, Nordstedt C, Greengard P, Czernik A
J Neurochem . 1999 Aug; 73(3):921-32. PMID: 10461881
Synaptotagmin I has been suggested to function as a low-affinity calcium sensor for calcium-triggered exocytosis from neurons and neuroendocrine cells. We have studied the phosphorylation of synaptotagmin I by a...
7.
Haggqvist B, Naslund J, Sletten K, Westermark G, Mucchiano G, Tjernberg L, et al.
Proc Natl Acad Sci U S A . 1999 Jul; 96(15):8669-74. PMID: 10411933
Aortic medial amyloid is a form of localized amyloid that occurs in virtually all individuals older than 60 years. The importance and impact of the amyloid deposits are unknown. In...
8.
Bohrmann B, Tjernberg L, Kuner P, Poli S, Levet-Trafit B, Naslund J, et al.
J Biol Chem . 1999 May; 274(23):15990-5. PMID: 10347147
We report that certain plasma proteins, at physiological concentrations, are potent inhibitors of amyloid beta-peptide (Abeta) polymerization. These proteins are also present in cerebrospinal fluid, but at low concentrations having...
9.
Fienberg A, Nordstedt C, Belting H, Czernik A, Nairn A, Gandy S, et al.
J Exp Zool . 1999 May; 285(1):76-84. PMID: 10327653
In an effort to characterize the signal transduction mechanisms that operate to regulate homeodomain protein function, we have analyzed the phosphorylation state of two homeodomain proteins, Hoxb-6 and Hoxc-8, in...
10.
Tjernberg L, Callaway D, Tjernberg A, Hahne S, Lilliehook C, Terenius L, et al.
J Biol Chem . 1999 Apr; 274(18):12619-25. PMID: 10212241
Polymerization of the amyloid beta (Abeta) peptide into protease-resistant fibrils is a significant step in the pathogenesis of Alzheimer's disease. It has not been possible to obtain detailed structural information...