C Michael Foley
Overview
Explore the profile of C Michael Foley including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
223
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0
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Recent Articles
11.
Wilsey A, Koshman Y, Weisbecker D, Bird B, Mirakhur K, Sadilek S, et al.
Comp Med
. 2021 Apr;
71(2):133-140.
PMID: 33814031
Successful implementation of automated blood sampling (ABS) into a telemetry instrumented canine cardiovascular model provides simultaneous cardiovascular assessment of novel compounds while collecting multiple blood samples for analysis of drug...
12.
Vargas H, Rolf M, Wisialowski T, Achanzar W, Bahinski A, Bass A, et al.
Clin Pharmacol Ther
. 2020 Sep;
109(2):310-318.
PMID: 32866317
Defining an appropriate and efficient assessment of drug-induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide....
13.
Authier S, Abernathy M, Correll K, Chui R, Dalton J, Foley C, et al.
Int J Toxicol
. 2020 May;
39(4):274-293.
PMID: 32406289
Introduction: The Safety Pharmacology Society (SPS) conducted a membership survey to examine industry practices related mainly to cardiovascular (CV) safety pharmacology (SP). Methods: Questions addressed nonclinical study design, data analysis...
14.
Ribeiro A, Guth B, Engwall M, Eldridge S, Foley C, Guo L, et al.
Front Pharmacol
. 2019 Sep;
10:934.
PMID: 31555128
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the...
15.
Guth B, Engwall M, Eldridge S, Foley C, Guo L, Gintant G, et al.
Front Pharmacol
. 2019 Aug;
10:884.
PMID: 31447679
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dt) in conscious animals, and such studies are...
16.
Chiang A, Guth B, Pugsley M, Foley C, Doyle J, Engwall M, et al.
J Pharmacol Toxicol Methods
. 2018 Mar;
92:43-51.
PMID: 29505899
Introduction: The sensitivity of a given test to detect a treatment-induced effect in a variable of interest is intrinsically related to the variability of that variable observed without treatment and...
17.
Kremer J, Bills A, Hanke N, Chen H, Meier W, Osinski M, et al.
J Pharmacol Toxicol Methods
. 2015 May;
75:27-37.
PMID: 26001324
Introduction: Nonclinical safety studies are increasingly incorporating cardiac safety endpoints to discover potential cardiovascular liabilities. This trend for more thorough cardiovascular nonclinical safety evaluation is prudent given the high attrition...
18.
Mitchell A, Bills A, Wittwer G, Foley C, Kremer J, Chen H, et al.
J Pharmacol Toxicol Methods
. 2013 May;
68(1):62-73.
PMID: 23639348
Introduction: Dogs are commonly used in cardiovascular drug safety assessment, and implanted telemetry models include subcutaneous or epicardial electrocardiogram (ECG) electrode placements. The purpose of this study was to determine...
19.
Martins-Pinge M, Mueller P, Foley C, Heesch C, Hasser E
Front Physiol
. 2013 Jan;
3:490.
PMID: 23316170
The paraventricular nucleus (PVN) of the hypothalamus is an important site for autonomic and neuroendocrine regulation. Experiments in anesthetized animals and in vitro indicate an interaction among gamma-aminobutyric acid (GABA),...
20.
Heesch C, Zheng H, Foley C, Mueller P, Hasser E, Patel K
Brain Res
. 2008 Dec;
1251:140-50.
PMID: 19041855
Pregnancy is characterized by elevated heart rate and decreased total peripheral resistance and arterial blood pressure. Plasma volume is expanded and plasma osmolality is decreased, yet vasopressin secretion in pregnant...