C M Zacharchuk
Overview
Explore the profile of C M Zacharchuk including associated specialties, affiliations and a list of published articles.
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21
Citations
297
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Recent Articles
1.
Memon S, Hou J, Moreno M, Zacharchuk C
J Immunol
. 1998 Mar;
160(5):2046-9.
PMID: 9498739
Current models for Fas (CD95)-mediated apoptosis suggest that FLICE/caspase-8 is recruited and activated, which results in cell death. However, the role of additional molecules in Fas signaling and FLICE activation...
2.
Henkart P, Williams M, Zacharchuk C, Sarin A
Semin Immunol
. 1997 Apr;
9(2):135-44.
PMID: 9194224
Inhibitors of ICE-family proteases (caspases) block many examples of apoptotic cell death in vivo and in vitro, including multiple apoptotic stimuli for T lymphocytes. We have tested whether cell death...
3.
Sarin A, Williams M, Berzofsky J, Zacharchuk C, Henkart P
Immunity
. 1997 Feb;
6(2):209-15.
PMID: 9047242
Activation of ICE/Ced-3 family proteases (caspases) has been proposed to mediate both the granule exocytosis and Fas-Fas ligand pathways of rapid target cell death by cytotoxic T lymphocytes. In agreement...
4.
Lenczowski J, Dominguez L, Eder A, King L, Zacharchuk C, Ashwell J
Mol Cell Biol
. 1997 Jan;
17(1):170-81.
PMID: 8972197
Cross-linking of Fas (CD95) induces apoptosis, a response that has been reported to depend upon the Ras activation pathway. Since many examples of apoptosis have been reported to involve AP-1...
5.
Vance B, Zacharchuk C, Segal D
J Biol Chem
. 1996 Nov;
271(48):30811-5.
PMID: 8940062
Bcl-2 is a cytoplasmic integral membrane protein with potent anti-apoptotic activity but whose mechanism of action is poorly understood. The purpose of this paper was to obtain large amounts of...
6.
Moreno M, Memon S, Zacharchuk C
J Immunol
. 1996 Nov;
157(9):3845-9.
PMID: 8892614
Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells. Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading...
7.
Memon S, Moreno M, Petrak D, Zacharchuk C
J Immunol
. 1995 Nov;
155(10):4644-52.
PMID: 7594463
Overexpression of Bcl-2 can prevent or markedly delay cell death induced by a variety of apoptotic stimuli. Although Fas and Fas ligand (FasL) interactions play a major role in the...
8.
Bakacs T, Lee J, Moreno M, Zacharchuk C, Cole M, Tso J, et al.
Int Immunol
. 1995 Jun;
7(6):947-55.
PMID: 7577803
In the present study we tested whether T cells retargeted with a bispecific antibody (bsAb) could block the growth of lung metastases of syngeneic mammary adenocarcinoma in immunocompetent mice. BALB/c...
9.
Memon S, Petrak D, Moreno M, Zacharchuk C
J Immunol Methods
. 1995 Mar;
180(1):15-24.
PMID: 7897244
Programmed cell death (PCD) has been observed in a wide variety of cell types in response to physiologic signals or types of stress. How these stimuli trigger PCD, and whether...
10.
Moreno M, Titus J, Cole M, Tso J, Le N, Paik C, et al.
Cancer Immunol Immunother
. 1995 Mar;
40(3):182-90.
PMID: 7728777
Bispecific antibodies with specificity for CD3 and a tumor antigen can redirect cytolytic T cells to kill tumor targets, regardless of their natural specificity. To assess the clinical potential of...