C M Fryling
Overview
Explore the profile of C M Fryling including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
186
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Recent Articles
1.
Mrsny R, Daugherty A, Fryling C, Fitzgerald D
Vaccine
. 1999 Apr;
17(11-12):1425-33.
PMID: 10195778
We have used a mouse immunization model to evaluate the potential for a chimera protein composed of a nontoxic form of Pseudomonas exotoxin (ntPE) to incite and sustain a mucosal...
2.
Fitzgerald D, Fryling C, McKee M, Vennari J, Wrin T, Cromwell M, et al.
J Biol Chem
. 1998 May;
273(16):9951-8.
PMID: 9545339
To develop a candidate vaccine for human immunodeficiency virus, type 1 (HIV-1), chimeric proteins were constructed by inserting sequences derived from the V3 loop of gp120 into a nontoxic form...
3.
Chiron M, Fryling C, Fitzgerald D
J Biol Chem
. 1998 Feb;
272(50):31707-11.
PMID: 9395513
Pseudomonas exotoxin (PE) requires proteolytic cleavage to generate a 37-kDa C-terminal fragment that translocates to the cytosol and ADP-ribosylates elongation factor 2. Cleavage within cells is mediated by furin, occurs...
4.
Fitzgerald D, Fryling C, Zdanovsky A, Saelinger C, Kounnas M, Winkles J, et al.
J Cell Biol
. 1995 Jun;
129(6):1533-41.
PMID: 7790352
The alpha 2-macroglobulin (alpha 2M) receptor/low-density lipoprotein receptor-related protein (LRP) is important for the clearance of proteases, protease-inhibitor complexes, and various ligands associated with lipid metabolism. While the regulation of...
5.
Fitzgerald D, Fryling C, Zdanovsky A, Saelinger C, Kounnas M, Strickland D, et al.
Ann N Y Acad Sci
. 1994 Sep;
737:138-44.
PMID: 7944142
No abstract available.
6.
Chiron M, Fryling C, Fitzgerald D
J Biol Chem
. 1994 Jul;
269(27):18167-76.
PMID: 8027078
Pseudomonas exotoxin (PE) is cleaved within mammalian cells between Arg279 and Gly280 to generate an enzymatically active COOH-terminal fragment of 37 kDa which translocates to the cytosol and ADP-ribosylates elongation...
7.
Ogata M, Fryling C, Pastan I, Fitzgerald D
J Biol Chem
. 1992 Dec;
267(35):25396-401.
PMID: 1460035
Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease within cells and then reduced to generate two prominent fragments (Ogata, M., Chaudhary, V. K., Pastan,...
8.
Tomasselli A, Hui J, Sawyer T, Staples D, Bannow C, Reardon I, et al.
J Virol
. 1990 Jul;
64(7):3157-61.
PMID: 2161935
The virally encoded proteases from human immunodeficiency virus (HIV) and avian myeloblastosis virus (AMV) have been compared relative to their ability to hydrolyze a variant of the three-domain Pseudomonas exotoxin,...
9.
Stromberg K, Hudgins W, Fryling C, Hazarika P, Dedman J, Pardue R, et al.
J Cell Biochem
. 1986 Jan;
32(4):247-59.
PMID: 3492500
Extracts of serum-free conditioned medium from human rhabdomyosarcoma A673 cells contain high molecular weight (HMW) transforming growth factors (TGFs) that can be partially purified by Bio-Gel P-100 and carboxymethyl (CM)-cellulose...
10.
Iwata K, Fryling C, Knott W, Todaro G
Cancer Res
. 1985 Jun;
45(6):2689-94.
PMID: 3857121
Two types of growth-modulating factors were derived from the serum-free conditioned media of a human rhabdomyosarcoma cell line, A673. One type, Mr 18,000 to 22,000, competes for binding to epidermal...