C Lengauer
Overview
Explore the profile of C Lengauer including associated specialties, affiliations and a list of published articles.
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55
Citations
7909
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Recent Articles
1.
Jallepalli P, Lengauer C
Nat Rev Cancer
. 2002 Mar;
1(2):109-17.
PMID: 11905802
Mitosis is the most dramatic--and potentially dangerous--event in the cell cycle, as sister chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that normally maintain the fidelity of...
2.
Lengauer C
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12331-3.
PMID: 11675484
No abstract available.
3.
Saha S, Bardelli A, Buckhaults P, Velculescu V, Rago C, St Croix B, et al.
Science
. 2001 Oct;
294(5545):1343-6.
PMID: 11598267
To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal...
4.
Caballero O, Cohen D, Liu Q, Esteller M, Bonacum J, White P, et al.
Genes Chromosomes Cancer
. 2001 Sep;
32(2):119-25.
PMID: 11550279
The accumulation of genetic alterations in the respiratory epithelium may give rise to cancer and often is accompanied by a series of histologic alterations over a period of several years....
5.
Langer S, Jentsch I, Gangnus R, Yan H, Lengauer C, Speicher M
Cytogenet Cell Genet
. 2001 Jul;
93(1-2):11-5.
PMID: 11474169
Recent evidence suggests that haplotype analysis is essential in recognizing genetic factors involved in the tendency toward a particular disease or pharmacogenetic phenotype, as well as to identify genes involved...
6.
Jallepalli P, Waizenegger I, Bunz F, Langer S, Speicher M, Peters J, et al.
Cell
. 2001 May;
105(4):445-57.
PMID: 11371342
Abnormalities of chromosome number are the most common genetic aberrations in cancer. The mechanisms regulating the fidelity of mitotic chromosome transmission in mammalian cells are therefore of great interest. Here...
7.
Bardelli A, Cahill D, Lederer G, Speicher M, Kinzler K, Vogelstein B, et al.
Proc Natl Acad Sci U S A
. 2001 Apr;
98(10):5770-5.
PMID: 11296254
It has been proposed recently that the type of genetic instability in cancer cells reflects the selection pressures exerted by specific carcinogens. We have tested this hypothesis by treating immortal,...
8.
Thiagalingam S, Laken S, WILLSON J, Markowitz S, Kinzler K, Vogelstein B, et al.
Proc Natl Acad Sci U S A
. 2001 Feb;
98(5):2698-702.
PMID: 11226302
Losses of heterozygosity are the most common molecular genetic alteration observed in human cancers. However, there have been few systematic studies to understand the mechanism(s) responsible for losses of heterozygosity...
9.
Shih I, Zhou W, Goodman S, Lengauer C, Kinzler K, Vogelstein B
Cancer Res
. 2001 Feb;
61(3):818-22.
PMID: 11221861
Chromosomal instability is believed to be a common feature of most human tumors, but the stage at which such instability originates has not been defined. At the molecular level, chromosomal...
10.
St Croix B, Rago C, Velculescu V, Traverso G, Romans K, Montgomery E, et al.
Science
. 2000 Aug;
289(5482):1197-202.
PMID: 10947988
To gain a molecular understanding of tumor angiogenesis, we compared gene expression patterns of endothelial cells derived from blood vessels of normal and malignant colorectal tissues. Of over 170 transcripts...