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C Lecut

Explore the profile of C Lecut including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 82
Followers 0
Related Specialties
Hematology
Biochemistry
Top 10 Co-Authors
C Oury
M Jandrot-Perrus
C Delierneux
K Sakamoto
P Luchetta
S Eeckhoudt
N Morel
J A Eble
C Gachet
H M H Spronk
Published In
J Thromb Haemost
Eur J Biochem
J Biol Chem
Affiliations
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Recent Articles
1.
Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides
Delierneux C, Donis N, Servais L, Wera O, Lecut C, Vandereyken M, et al.
J Thromb Haemost . 2017 Mar; 15(5):983-997. PMID: 28296036
Summary: Background Synthetic phosphorothioate-modified CpG oligodeoxynucleotides (ODNs) show potent immunostimulatory properties that are widely exploited in clinical trials of anticancer treatment. Unexpectedly, a recent study indicated that CpG ODNs activate...
2.
The Ca(2+) /calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets
Onselaer M, Oury C, Hunter R, Eeckhoudt S, Barile N, Lecut C, et al.
J Thromb Haemost . 2014 Mar; 12(6):973-86. PMID: 24655923
Background: Platelet activation requires sweeping morphologic changes, supported by contraction and remodeling of the platelet actin cytoskeleton. In various other cell types, AMP-activated protein kinase (AMPK) controls the phosphorylation state...
3.
ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation
Lecut C, Faccinetto C, Delierneux C, van Oerle R, Spronk H, Evans R, et al.
J Thromb Haemost . 2012 Jan; 10(3):453-65. PMID: 22212928
Background: In sepsis, extracellular ATP, secreted by activated platelets and leukocytes, may contribute to the crosstalk between hemostasis and inflammation. Previously, we showed that, in addition to their role in...
4.
Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments
Lecut C, Feeney L, Kingsbury G, Hopkins J, Lanza F, Gachet C, et al.
J Thromb Haemost . 2003 Dec; 1(12):2653-62. PMID: 14675102
Platelet interactions with adhesive ligands exposed at sites of vascular injury initiate the normal hemostatic response but may also lead to arterial thrombosis. Platelet membrane glycoprotein (GP)VI is a key...
5.
Expression and function of the collagen receptor GPVI during megakaryocyte maturation
Lagrue-Lak-Hal A, Debili N, Kingbury G, Lecut C, Le Couedic J, Villeval J, et al.
J Biol Chem . 2001 Mar; 276(18):15316-25. PMID: 11278467
In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord blood...
6.
Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2
Mounier C, Luchetta P, Lecut C, Koduri R, Faure G, Lambeau G, et al.
Eur J Biochem . 2000 Aug; 267(16):4960-9. PMID: 10931177
Human secreted group IIA phospholipase A2 (hGIIA) was reported to inhibit prothrombinase activity because of binding to factor Xa. This study further shows that hGIIA and its catalytically inactive H48Q...