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C Laker

Explore the profile of C Laker including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 148
Followers 0
Related Specialties
Nursing
Psychiatry
Hematology
Top 10 Co-Authors
W Ostertag
C Stocking
J Friel
M J Franz
N KLUGE
U Just
C Flach
M Dexter
J Nowock
T Wykes
Published In
J Virol
J Psychiatr Ment Health Nurs
Haematol Blood Transfus
Leukemia
Trop Anim Health Prod
Affiliations
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Recent Articles
11.
Selectable retrovirus vectors encoding Friend virus gp55 or erythropoietin induce polycythemia with different phenotypic expression and disease progression
Ahlers N, Hunt N, Just U, Laker C, Ostertag W, Nowock J
J Virol . 1994 Nov; 68(11):7235-43. PMID: 7933106
The Friend spleen focus-forming virus induces a massive expansion of erythroid progenitor cells resulting in polycythemia and splenomegaly. The pathogenic agent is the membrane glycoprotein gp55, encoded by the env...
12.
Abrogation of the requirement for feeder cell interaction and T cell receptor stimulation of lymphocytes infected with retroviral vectors
Laker C, Graning G, Kelso A, Stocking C, Ostertag W
J Exp Med . 1990 Aug; 172(2):447-56. PMID: 2165126
Infection of sensitive adult mice with myeloproliferative sarcoma virus (MPSV) results in a myeloproliferative syndrome. Two components of the viral genome are required to induce this unique pathology: the mos...
13.
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat
Friel J, Hughes D, Pragnell I, Stocking C, Laker C, Nowock J, et al.
J Virol . 1990 Jan; 64(1):369-78. PMID: 2152823
The malignant histiocytosis sarcoma virus (MHSV), in contrast to other viruses with the ras oncogene, induces acute histiocytosis in newborn and adult mice. Molecular structure and function studies were initiated...
14.
Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene
Laker C, KLUGE N, Stocking C, Just U, Franz M, Ostertag W, et al.
Mol Cell Biol . 1989 Dec; 9(12):5746-9. PMID: 2586530
At least two separate but interdependent events are required to attain autonomous growth as a consequence of ectopic expression of the multilineage colony-stimulating factor gene in hematopoietic progenitor cells. The...
15.
Conversion of factor-dependent myeloid cells to factor independence: autocrine stimulation is not coincident with tumorigenicity
Stocking C, Kawai M, Laker C, Loliger C, KLUGE N, Klingler K, et al.
Curr Top Microbiol Immunol . 1989 Jan; 149:117-26. PMID: 2731434
It has been postulated that the disruption of the normal hormonal regulation of blood cell formation and proliferation leads to the autonomous growth of hematopoietic progenitors or stem cells and...
16.
Aberrant expression of the multi-CSF gene in hematopoietic precursor and stem cell lines initiates leukemogenic progression
Laker C, Stocking C, KLUGE N, Franz M, Spooncer E, Dexter M, et al.
Haematol Blood Transfus . 1989 Jan; 32:188-96. PMID: 2625246
Tumorigenesis of hemopoietic cells and acquisition of factor independence as a consequence of aberrant growth factor release are closely correlated. In previous work we were able to dissect two stages...
17.
Autocrine stimulation after transfer of the granulocyte/macrophage colony-stimulating factor gene and autonomous growth are distinct but interdependent steps in the oncogenic pathway
Laker C, Stocking C, Bergholz U, Hess N, De Lamarter J, Ostertag W
Proc Natl Acad Sci U S A . 1987 Dec; 84(23):8458-62. PMID: 3317408
Autocrine stimulation of cells by aberrant synthesis of growth factor may lead to malignant transformation, either as a direct consequence of endogenous factor production or as a first step of...