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C J Pazoles

Explore the profile of C J Pazoles including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 35
Citations 431
Followers 0
Related Specialties
Biochemistry
Biology
Pharmacology
Top 10 Co-Authors
H B Pollard
C E Creutz
A Ramu
O Zinder
L Svensson
C A Gabel
V L Cohan
J W Watson
J B Cheng
C R Turner
Published In
J Biol Chem
Anal Biochem
J Pharmacol Exp Ther
J Immunol
Proc Natl Acad Sci U S A
Affiliations
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Recent Articles
1.
Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic
Uys J, Manevich Y, Devane L, He L, Garret T, Pazoles C, et al.
Biomed Pharmacother . 2010 Apr; 64(7):493-8. PMID: 20359856
NOV-002 is a glutathione disulfide (GSSG) mimetic that is the subject of clinical investigation in oncology indications. GSSG is reduced by glutathione reductase (GR) to form glutathione (GSH), thereby maintaining...
2.
Enterococcus faecalis multi-drug resistance transporters: application for antibiotic discovery
Davis D, McAlpine J, Pazoles C, Talbot M, Alder E, White C, et al.
J Mol Microbiol Biotechnol . 2001 Apr; 3(2):179-84. PMID: 11321571
Using bioinformatics approaches, 34 potential multidrug resistance (MDR) transporter sequences representing 4 different transporter families were identified in the unannotated Enterococcus faecalis database (TIGR). A functional genomics campaign generating single-gene...
3.
The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy
Cheng J, Watson J, Pazoles C, Eskra J, Griffiths R, Cohan V, et al.
J Pharmacol Exp Ther . 1997 Feb; 280(2):621-6. PMID: 9023272
Rolipram was previously reported to elevate plasma cyclic adenosine 3',5'-monophosphate (cAMP) and inhibit serum tumor necrosis factor-alpha (TNF-alpha) production in mice. CP-80,633, a new cyclic nucleotide phosphodiesterase (PDE4) inhibitor, has...
4.
In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633
Cohan V, Showell H, Fisher D, Pazoles C, Watson J, Turner C, et al.
J Pharmacol Exp Ther . 1996 Sep; 278(3):1356-61. PMID: 8819523
We present the in vitro pharmacology of a novel adenosine 3'-5' -cyclic monophosphate-specific phosphodiesterase (PDE) type 4 inhibitor, CP-80633 ((2'S)5-[3-(2' -exobicyclo[2.2.1]-heptyloxy)4-methoxyphenyl] tetrahydro-2(1H)-primidone), which has shown efficacy in phase II clinical...
5.
The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4
Turner C, Cohan V, Cheng J, Showell H, Pazoles C, Watson J
J Pharmacol Exp Ther . 1996 Sep; 278(3):1349-55. PMID: 8819522
The following studies were conducted to characterize the bron-chodilatory and antiinflammatory activity of the novel, selective phosphodiesterase-IV inhibitor, CP-80,633 (2'S)5-[3-(2'-exobicyclo[2.2.1]heptyloxy-4-methoxy-phenyl]te trahydro- 2(1H)-pyrimidone, a compound in clinical development for atopic disease....
6.
Inhibition of cytokine activation processes in vitro by tenidap, a novel anti-inflammatory agent
McNiff P, Laliberte R, Svensson L, Pazoles C, Gabel C
Cytokine . 1995 Feb; 7(2):196-208. PMID: 7780040
Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence...
7.
Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. I. Mechanism and evidence of functional significance
McNiff P, Svensson L, Pazoles C, Gabel C
J Immunol . 1994 Sep; 153(5):2180-93. PMID: 8051419
Tenidap is a novel anti-inflammatory and antiarthritic agent that in clinical studies of rheumatoid arthritis patients, displays symptomatic efficacy superior to nonsteroidal anti-inflammatory drugs (NSAIDs) and equivalent to combinations of...
8.
Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. II. Inhibition of IL-1 beta production from ATP-treated monocytes and macrophages
LALIBERTE R, Perregaux D, Svensson L, Pazoles C, Gabel C
J Immunol . 1994 Sep; 153(5):2168-79. PMID: 8051418
IL-1 beta is an important inflammatory mediator produced by monocytes and macrophages after LPS stimulation. In the absence of a secondary stimulus, however, little IL-1 beta is released into the...
9.
A role for bombesin in sensory processing in the spinal cord
ODonohue T, Massari V, Pazoles C, Chronwall B, Shults C, Quirion R, et al.
J Neurosci . 1984 Dec; 4(12):2956-62. PMID: 6094746
Bombesin (BN)-containing neuronal processes were demonstrated in laminae I and II of the dorsal horn of the cat, rat, and mouse spinal cord by immunocytochemistry and radioimmunoassay. Dorsal rhizotomy in...
10.
An osmotic mechanism for exocytosis from dissociated chromaffin cells
Pollard H, Pazoles C, Creutz C, Scott J, Zinder O, Hotchkiss A
J Biol Chem . 1984 Jan; 259(2):1114-21. PMID: 6420400
Dissociated chromaffin cells from bovine adrenal medulla were stimulated to secrete epinephrine and dopamine beta-hydroxylase with a variety of secretagogues in a study designed to test the hypothesis that the...