C J McGlade
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Explore the profile of C J McGlade including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
884
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Recent Articles
1.
Rajendran D, Zhang Y, Berry D, McGlade C
Oncogene
. 2016 Apr;
35(39):5202-13.
PMID: 27041567
The endocytic adaptor protein Numb has a major role in development as an intrinsic regulator of cell fate determination and inhibitor of the Notch signaling pathway. In vertebrates, four protein...
2.
Gillis L, Berry D, Minden M, McGlade C, Barber D
Leukemia
. 2013 Feb;
27(8):1666-76.
PMID: 23399893
Philadelphia chromosome-positive leukemias, including chronic myeloid leukemia and B-cell acute lymphoblastic leukemia (B-ALL), are driven by the oncogenic BCR-ABL fusion protein. Animal modeling experiments utilizing retroviral transduction and subsequent bone...
3.
Yeh E, Dermer M, Commisso C, Zhou L, McGlade C, Boulianne G
Curr Biol
. 2001 Nov;
11(21):1675-9.
PMID: 11696324
The Notch pathway is a widely studied means of intercellular signaling responsible for the determination of cell fate, cell differentiation, and boundary formation (reviewed in ). The main effectors of...
4.
Liu S, Berry D, McGlade C
Oncogene
. 2001 Oct;
20(44):6284-90.
PMID: 11607830
Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase...
5.
Claudio J, Zhu Y, Benn S, Shukla A, McGlade C, Falcioni N, et al.
Oncogene
. 2001 Sep;
20(38):5373-7.
PMID: 11536050
SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that...
6.
Berry D, Benn S, Cheng A, McGlade C
Oncogene
. 2001 Apr;
20(10):1203-11.
PMID: 11313864
Gads is a SH2 and SH3 domain-containing, hematopoietic-specific adaptor protein that functions in signalling from the T cell receptor. Gads acts by linking SLP-76, bound by the carboxy-terminal Gads SH3...
7.
Asazuma N, Wilde J, Berlanga O, Leduc M, Leo A, SCHWEIGHOFFER E, et al.
J Biol Chem
. 2000 Aug;
275(43):33427-34.
PMID: 10942756
The snake venom toxin convulxin activates platelets through the collagen receptor glycoprotein VI (GPVI)/Fc receptor gamma-chain (FcR gamma-chain) complex leading to tyrosine phosphorylation and activation of the tyrosine Syk and...
8.
Liu S, Smith C, Arnold R, Kiefer F, McGlade C
J Immunol
. 2000 Jul;
165(3):1417-26.
PMID: 10903746
The hemopoietic-specific Gads (Grb2-related adaptor downstream of Shc) adaptor protein possesses amino- and carboxyl-terminal Src homology 3 (SH3) domains flanking a central SH2 domain and a unique region rich in...
9.
Zhang W, Trible R, Zhu M, Liu S, McGlade C, Samelson L
J Biol Chem
. 2000 May;
275(30):23355-61.
PMID: 10811803
The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated signaling and thymocyte development. Upon T cell activation, LAT becomes...
10.
Dho S, French M, Woods S, McGlade C
J Biol Chem
. 1999 Nov;
274(46):33097-104.
PMID: 10551880
Numb is a membrane-associated, phosphotyrosine binding (PTB) domain-containing protein that functions as an intrinsic determinant of cell fate during Drosophila development. We have identified four isoforms of mammalian Numb with...