C J Kenyon
Overview
Explore the profile of C J Kenyon including associated specialties, affiliations and a list of published articles.
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Articles
126
Citations
1987
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Recent Articles
1.
Wilson K, Tucker C, Al-Dujaili E, Holmes M, Hadoke P, Kenyon C, et al.
J Endocrinol
. 2016 Jul;
230(1):125-42.
PMID: 27390302
Glucocorticoids (GCs) in utero influence embryonic development with consequent programmed effects on adult physiology and pathophysiology and altered susceptibility to cardiovascular disease. However, in viviparous species, studies of these processes...
2.
Mullins L, Kenyon C, Bailey M, Conway B, Diaz M, Mullins J
Hypertension
. 2015 Aug;
66(3):e20.
PMID: 26269656
No abstract available.
3.
Rog-Zielinska E, Craig M, Manning J, Richardson R, Gowans G, Dunbar D, et al.
Cell Death Differ
. 2014 Nov;
22(7):1106-16.
PMID: 25361084
Glucocorticoid levels rise dramatically in late gestation to mature foetal organs in readiness for postnatal life. Immature heart function may compromise survival. Cardiomyocyte glucocorticoid receptor (GR) is required for the...
4.
Wilson K, Matrone G, Livingstone D, Al-Dujaili E, Mullins J, Tucker C, et al.
J Physiol
. 2013 Oct;
591(24):6209-20.
PMID: 24167225
While glucocorticoids (GCs) are known to be present in the zebrafish embryo, little is known about their physiological roles at this stage. We hypothesised that GCs play key roles in...
5.
Yang C, Nixon M, Kenyon C, Livingstone D, Duffin R, Rossi A, et al.
Br J Pharmacol
. 2011 May;
164(6):1661-71.
PMID: 21542833
Background And Purpose: Dissociating anti-inflammatory efficacy from the metabolic side effects of glucocorticoids is an attractive therapeutic goal. 5α-Tetrahydro-corticosterone (5αTHB), produced from corticosterone by 5α-reductases, activates glucocorticoid receptors. This study...
6.
Al-Dujaili E, Kenyon C, Nicol M, Mason J
Mol Cell Endocrinol
. 2010 Dec;
336(1-2):102-9.
PMID: 21184804
The mineralocorticoid effects of liquorice are mediated by the inhibitory effects of one of its active components glycyrrhetinic acid on 11β-hydroxysteroid dehydrogenase type 2. However, liquorice is reputed to have...
7.
ORegan D, Kenyon C, Seckl J, Holmes M
Lab Anim
. 2010 Jan;
44(3):199-205.
PMID: 20071412
Low birth weight in humans is predictive of hypertension in adult life, and while the mechanisms underlying this link remain unknown, fetal overexposure to glucocorticoids has been implicated. We have...
8.
Al-Dujaili E, Mullins L, Bailey M, Kenyon C
Steroids
. 2009 Jan;
74(4-5):456-62.
PMID: 19162057
Background: Clinical studies have established aldosterone as a critical physiological and pathophysiological factor in salt and water homeostasis, blood pressure control and in heart failure. Genetic and physiological studies of...
9.
Michailidou Z, Carter R, Marshall E, Sutherland H, Brownstein D, Owen E, et al.
FASEB J
. 2008 Aug;
22(11):3896-907.
PMID: 18697839
Glucocorticoid hormones are critical to respond and adapt to stress. Genetic variations in the glucocorticoid receptor (GR) gene alter hypothalamic-pituitary-adrenal (HPA) axis activity and associate with hypertension and susceptibility to...
10.
Hadoke P, Lindsay R, Seckl J, Walker B, Kenyon C
J Endocrinol
. 2006 Mar;
188(3):435-42.
PMID: 16522724
Excessive exposure to glucocorticoids during gestation reduces birth weight and induces permanent hypertension in adulthood. The mechanisms underlying this programmed elevation of blood pressure have not been established. We hypothesised...