C J Charles
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Explore the profile of C J Charles including associated specialties, affiliations and a list of published articles.
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54
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298
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Recent Articles
1.
Charles C, Rout S, Patel K, Akbar S, Laws A, Jackson B, et al.
Appl Environ Microbiol
. 2017 Jan;
83(6).
PMID: 28087527
The survival of microorganisms within a cementitious geological disposal facility for radioactive wastes heavily depends on their ability to survive the calcium-dominated, hyperalkaline conditions resulting from the dissolution of the...
2.
Charles C, Rout S, Garratt E, Patel K, Laws A, Humphreys P
FEMS Microbiol Ecol
. 2015 Jul;
91(8):fiv085.
PMID: 26195600
Anthropogenic hyperalkaline sites provide an environment that is analogous to proposed cementitious geological disposal facilities (GDF) for radioactive waste. Under anoxic, alkaline conditions cellulosic wastes will hydrolyze to a range...
3.
Roberts A, Trainor K, Weeks B, Jackson N, Troughton R, Charles C, et al.
J Histotechnol
. 2014 Sep;
36(1):17-24.
PMID: 25258469
The safety and efficacy of an implantable left atrial pressure (LAP) monitoring system is being evaluated in a clinical trial setting. Because the number of available specimens from the clinical...
4.
Patel K, Rademaker M, Kirkpatrick C, Charles C, Fisher S, Yandle T, et al.
Br J Pharmacol
. 2012 Feb;
166(6):1916-25.
PMID: 22339174
BACKGROUND AND PURPOSE The urocortin (Ucn) peptides are emerging as potential therapeutic targets for heart disease. However, pharmacokinetic (PK) and pharmacodynamic (PD) data are lacking. Therefore, we investigated the PK/PD...
5.
Jardine D, Charles C, Frampton C, Richards A
Am J Physiol Heart Circ Physiol
. 2007 Mar;
293(1):H433-9.
PMID: 17369457
The association between cardiac sympathetic nerve activity (CSNA) and ventricular fibrillation (VF) during acute myocardial infarction (MI) has not been assessed in conscious animal models. During the first 60 min...
6.
Charles C, Jardine D, Nicholls M, Richards A
J Endocrinol
. 2005 Nov;
187(2):275-81.
PMID: 16293775
The sympathetic nervous system and adrenomedullin (AM) both participate in the regulation of cardiac and circulatory function but their interaction remains uncertain. We have examined the effects of AM on...
7.
Jardine D, Charles C, Ashton R, Bennett S, Whitehead M, Frampton C, et al.
J Physiol
. 2005 Mar;
565(Pt 1):325-33.
PMID: 15774526
The time course of cardiac sympathetic nerve activity (CSNA) following acute myocardial infarction (MI) is unknown. We therefore undertook serial direct recordings of CSNA, arterial blood pressure (MAP) and heart...
8.
Jardine D, Charles C, Forrester M, Whitehead M, Nicholls M
Clin Auton Res
. 2003 Oct;
13(5):339-41.
PMID: 14564657
By monitoring efferent cardiac sympathetic nerve activity (CSNA) directly in a conscious animal we observed, for the first time, that ventricular fibrillation (VF) following myocardial infarction (MI) was preceded by...
9.
Adrenomedullin modulates the neurohumoral response to acute volume loading in normal conscious sheep
Charles C, Nicholls M, Rademaker M, Richards A
J Endocrinol
. 2002 Apr;
173(1):123-9.
PMID: 11927391
The physiological role of adrenomedullin (ADM) in volume and pressure homeostasis remains unclear. Accordingly, we assessed possible modulatory actions of ADM infusions on the neurohumoral response to acute volume loading...
10.
Comparative actions of adrenomedullin and nitroprusside: interactions with ANG II and norepinephrine
Charles C, Nicholls M, Rademaker M, Richards A
Am J Physiol Regul Integr Comp Physiol
. 2001 Nov;
281(6):R1887-94.
PMID: 11705774
The role of adrenomedullin (ADM) in volume and pressure homeostasis remains undefined. Accordingly, we compared the biological responses to infusions of ADM and nitroprusside (NP; matched for reduction of arterial...