C J Canfield
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Explore the profile of C J Canfield including associated specialties, affiliations and a list of published articles.
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55
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1408
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Recent Articles
1.
Jensen N, Ager A, Bliss R, Canfield C, Kotecka B, Rieckmann K, et al.
J Med Chem
. 2001 Nov;
44(23):3925-31.
PMID: 11689078
A total of 34 analogues of the biguanide PS-15 (5s), a prodrug of the diaminotriazine WR-99210 (8s), have been prepared. Several of them, such as 5b (PS-33) and 5m (PS-26),...
2.
Llanos-Cuentas A, Campos P, Clendenes M, Canfield C, Hutchinson D
Braz J Infect Dis
. 2001 Aug;
5(2):67-72.
PMID: 11493411
The efficacy and safety of a fixed-dose combination of atovaquone and proguanil hydrochloride (Malarone) were compared with chloroquine or pyrimethamine/sulfadoxine in patients with acute falciparum malaria in northern Peru. Patients...
3.
Mulenga M, Sukwa T, Canfield C, Hutchinson D
Clin Ther
. 1999 Jul;
21(5):841-52.
PMID: 10397379
Atovaquone and proguanil hydrochloride are blood schizonticides that demonstrate in vitro synergy against drug-resistant strains of Plasmodium falciparum. When coadministered, they may therefore be effective for the treatment of malaria...
4.
Anabwani G, Canfield C, Hutchinson D
Pediatr Infect Dis J
. 1999 Jun;
18(5):456-61.
PMID: 10353520
Background: Malaria is a major cause of pediatric mortality in sub-Saharan Africa. Worldwide estimates of mortality among children with Plasmodium falciparum malaria range from 1 to 2 million deaths per...
5.
Looareesuwan S, Chulay J, Canfield C, Hutchinson D
Am J Trop Med Hyg
. 1999 May;
60(4):533-41.
PMID: 10348225
The continuing spread of drug-resistant malaria emphasizes the need for new antimalarial drugs. Atovaquone is a broad-spectrum antiprotozoal drug with a novel mechanism of action, via inhibition of parasite mitochondrial...
6.
Looareesuwan S, Wilairatana P, Chalermarut K, Rattanapong Y, Canfield C, Hutchinson D
Am J Trop Med Hyg
. 1999 May;
60(4):526-32.
PMID: 10348224
The increasing frequency of therapeutic failures in falciparum malaria underscores the need for novel, rapidly effective antimalarial drugs or drug combinations. Atovaquone and proguanil are blood schizonticides that demonstrate synergistic...
7.
Bustos D, Canfield C, Hutchinson D
J Infect Dis
. 1999 May;
179(6):1587-90.
PMID: 10228090
This randomized, open-label clinical trial compared a fixed-dose combination of atovaquone and proguanil (n=55) with chloroquine (n=23) or a combination of chloroquine, sulfadoxine, and pyrimethamine (n=32) for treatment of acute...
8.
Sabchareon A, Attanath P, Phanuaksook P, Chanthavanich P, Poonpanich Y, Mookmanee D, et al.
Trans R Soc Trop Med Hyg
. 1998 Oct;
92(2):201-6.
PMID: 9764334
A trial was conducted in 32 Thai children with uncomplicated multidrug-resistant falciparum malaria to assess the efficacy, safety and pharmacokinetics of atovaquone and proguanil; plasma concentrations of atovaquone, proguanil and...
9.
Hussein Z, Eaves J, Hutchinson D, Canfield C
Clin Pharmacol Ther
. 1997 May;
61(5):518-30.
PMID: 9164414
The population pharmacokinetics of atovaquone were examined in 458 black, Oriental, and Malay patients with acute Plasmodium falciparum malaria receiving atovaquone alone or concomitantly with other drugs. Oral clearance (CL/F)...
10.
Hussein Z, Eaves C, Hutchinson D, Canfield C
Br J Clin Pharmacol
. 1996 Nov;
42(5):589-97.
PMID: 8951190
1. The pharmacokinetics of proguanil were evaluated in patients with acute P. falciparum malaria receiving concomitantly proguanil hydrochloride and atovaquone. The population consisted of 203 Blacks, 112 Orientals and 55...