C F McTiernan
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Explore the profile of C F McTiernan including associated specialties, affiliations and a list of published articles.
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29
Citations
973
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Recent Articles
1.
McTiernan C, Mathier M, Zhu X, Xiao X, Klein E, Swan C, et al.
Gene Ther
. 2007 Sep;
14(23):1613-22.
PMID: 17851548
Sequestration of tumor necrosis factor-alpha (TNFalpha) by TNF-receptor immunoglobulin G (IgG)-Fc fusion proteins can limit heart failure progression in rodent models. In this study we directly injected an adeno-associated viruses...
2.
Li Y, Mi Z, Feng Y, McTiernan C, Zhou R, Robbins P, et al.
Am J Physiol Heart Circ Physiol
. 2001 Nov;
281(6):H2738-46.
PMID: 11709443
Eph receptors constitute the largest family of receptor tyrosine kinases. Multiple transcripts of ephrin-A5, the cognate ligand of the EphA3 receptor, were found in neonatal rat cardiomyocytes. Two cDNA clones...
3.
Li Y, Feng Y, McTiernan C, Pei W, Moravec C, Wang P, et al.
Circulation
. 2001 Sep;
104(10):1147-52.
PMID: 11535571
Background: Left ventricular assist device (LVAD) support of the failing heart induces salutary changes in myocardial structure and function. Matrix metalloproteinases (MMPs) are increased in the failing heart and are...
4.
Kadokami T, Frye C, Lemster B, Wagner C, Feldman A, McTiernan C
Circulation
. 2001 Sep;
104(10):1094-7.
PMID: 11535561
Background: - Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of congestive heart failure. A strain of transgenic mice (TNF1.6) with cardiac-specific overexpression of TNF-alpha develop congestive heart...
5.
Kubota T, Miyagishima M, FRYE C, Alber S, Bounoutas G, Kadokami T, et al.
J Mol Cell Cardiol
. 2001 Jul;
33(7):1331-44.
PMID: 11437539
We have previously reported that mice with cardiac-specific overexpression of tumor necrosis factor (TNF)- alpha develop myocardial inflammation, cardiac hypertrophy, and dilated cardiomyopathy. TNF- alpha is reported to induce apoptosis...
6.
Lu C, Schwartzbauer G, Sperling M, Devaskar S, Thamotharan S, Robbins P, et al.
J Biol Chem
. 2001 Apr;
276(25):22892-900.
PMID: 11303022
The cellular and molecular basis of growth hormone (GH) actions on the heart remain poorly defined, and it is unclear whether GH effects on the myocardium are direct or mediated...
7.
Kadokami T, McTiernan C, Kubota T, FRYE C, Bounoutas G, Robbins P, et al.
Am J Physiol Heart Circ Physiol
. 2001 Apr;
280(5):H2281-91.
PMID: 11299232
Tumor necrosis factor (TNF)-alpha plays a key role in the pathogenesis of septic shock syndrome, and myocardial TNF-alpha expression may contribute to this pathophysiology. We examined the myocardial expression of...
8.
Feldman A, Li Y, McTiernan C
Lancet
. 2001 Mar;
357(9257):654-5.
PMID: 11247546
No abstract available.
9.
Li Y, Feng Y, Kadokami T, McTiernan C, Draviam R, Watkins S, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(23):12746-51.
PMID: 11070088
Myocardial fibrosis caused by maladaptive extracellular matrix (ECM) remodeling is implicated in the dysfunction of the failing heart. Matrix metalloproteinases (MMPs) regulate ECM remodeling, and are regulated by cytokines. Transgenic...
10.
Stull L, DiIulio N, Yu M, McTiernan C, Ratliff N, Tuohy V, et al.
J Mol Cell Cardiol
. 2000 Oct;
32(11):2035-49.
PMID: 11040107
Although myocarditis has been implicated in the pathogenesis of heart failure, a definitive relationship between myocardial inflammation, cardiac dysfunction, and changes in myocyte gene expression has not been established. In...