C E Smithen
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Explore the profile of C E Smithen including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
163
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Recent Articles
1.
Adams G, Flockhart I, Smithen C, Stratford I, Wardman P, Watts M
Radiat Res
. 2012 Aug;
178(2):AV183-9.
PMID: 22870968
No abstract available.
2.
Self C, Barber W, Machin P, OSBOND J, Smithen C, Tong B, et al.
J Med Chem
. 1991 Feb;
34(2):772-7.
PMID: 1995900
The synthesis of a series of substituted heterocyclic alkoxypropionic acids is described. They were evaluated for antiinflammatory effects in two animal models of chronic inflammation; adjuvant arthritis and type II...
3.
Workman P, NEWMAN H, Bleehen N, WARD R, Smithen C
Cancer Chemother Pharmacol
. 1991 Jan;
28(2):118-22.
PMID: 2060082
During a clinical toxicity study it was possible to obtain urine samples from six patients receiving either the R-(-)- or S-(+)-stereoenantiomeric forms of the developmental 2-nitroimidazole radiosensitizer Ro 03-8799 (pimonidazole)....
4.
NEWMAN H, Dunphy E, Bleehen N, Dische S, Saunders M, des Rochers C, et al.
Br J Radiol
. 1986 Oct;
59(706):997-9.
PMID: 3768642
The maximum single dose of the 2-nitroimidazole hypoxic cell radiosensitiser Ro 03-8799 is limited to 1 g/m2 by the occurrence of a well characterised acute syndrome of sweating, nausea and...
5.
Millar B, Jenkins T, Smithen C, Jinks S
Radiat Res
. 1985 Jan;
101(1):111-22.
PMID: 3969438
Bothtrans-N,N'-bis(2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl)-1, 2-diaminocyclopropane[Ro31-2269] and its cis isomer [Ro 31-2778] selectively sensitized hypoxic Chinese hamster cells, line V-79-753B, to radiation by decreasing both the D0 value and extrapolation number, whereas a related...
6.
Wardman P, Anderson R, Hodgkiss R, Parrick J, Smithen C, Wallace R, et al.
Int J Radiat Oncol Biol Phys
. 1982 Mar;
8(3-4):399-401.
PMID: 7050038
The effects of 23 non-nitro compounds on the radiosensitivity of hypoxic Chinese hamster V79-379A or E. coli AB 1157 cells in vitro are outlined. Imidazole derivatives substituted with several alternative...
7.
Denekamp J, Michael B, Minchinton A, Smithen C, Stewart F, Stratford M, et al.
Br J Cancer
. 1982 Feb;
45(2):247-55.
PMID: 7059473
The survival of epidermal cells in vivo has been used to assess potential radiosensitizers. Mouse skin was made acutely hypoxic for the irradiations, to give radioprotection by a factor of...
8.
Adams G, Clarke E, Gray P, Jacobs R, Stratford I, Wardman P, et al.
Int J Radiat Biol Relat Stud Phys Chem Med
. 1979 Feb;
35(2):151-60.
PMID: 312784
This paper describes measurements of the aerobic cytotoxicity of 42 nitroaromatic and nitroheterocyclic compounds towards Chinese Hamster cells in vitro. The results of acute and chronic exposure were quantified, and...
9.
Adams G, Clarke E, Flockhart I, Jacobs R, Sehmi D, Stratford I, et al.
Int J Radiat Biol Relat Stud Phys Chem Med
. 1979 Feb;
35(2):133-50.
PMID: 312783
The efficiency of 35 nitroaromatic and nitroheterocyclic compounds in radiosensitizing hypoxic Chinese Hamster cells in vitro was determined. The concentration C of the compound required to achieve an enhancement ratio...
10.
Anderson R, Patel K, Smithen C
Br J Cancer Suppl
. 1978 Jun;
3:103-6.
PMID: 354674
The two nitropyridinium compounds tested sensitize hypoxic Serratia marcescens to irradiation up to the oxygen enhancement level by two components which can be separated as a function of compound concentration....