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C E Hirst

Explore the profile of C E Hirst including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 6
Citations 272
Followers 0
Related Specialties
Cell Biology
Molecular Biology
Endocrinology
Top 10 Co-Authors
P I Bird
C H Bird
J Sun
M S Buzza
V R Sutton
J A Trapani
L C Harrison
E G Stanley
J McKendrick
S Kumar
Published In
Mol Cell Biol
Mol Hum Reprod
Blood
Diabetologia
Cell Immunol
Affiliations
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Recent Articles
1.
INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells
Micallef S, Li X, Schiesser J, Hirst C, Yu Q, Lim S, et al.
Diabetologia . 2011 Nov; 55(3):694-706. PMID: 22120512
Aims/hypothesis: We aimed to generate human embryonic stem cell (hESC) reporter lines that would facilitate the characterisation of insulin-producing (INS⁺) cells derived in vitro. Methods: Homologous recombination was used to...
2.
Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction
Hirst C, Buzza M, Sutton V, Trapani J, Loveland K, Bird P
Mol Hum Reprod . 2001 Nov; 7(12):1133-42. PMID: 11719590
Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and...
3.
The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses
Buzza M, Hirst C, Bird C, Hosking P, McKendrick J, Bird P
Cell Immunol . 2001 Aug; 210(1):21-9. PMID: 11485349
Proteinase inhibitor 9 (PI-9) is a 42-kDa human intracellular serpin present in cytotoxic lymphocytes (CLs). PI-9 is an extremely efficient inhibitor of the pro-apoptotic CL granule proteinase granzyme B and...
4.
Nucleocytoplasmic distribution of the ovalbumin serpin PI-9 requires a nonconventional nuclear import pathway and the export factor Crm1
Bird C, Blink E, Hirst C, Buzza M, Steele P, Sun J, et al.
Mol Cell Biol . 2001 Jul; 21(16):5396-407. PMID: 11463822
Proteinase inhibitor 9 (PI-9) is a human serpin present in the cytoplasm of cytotoxic lymphocytes and epithelial cells. It inhibits the cytotoxic lymphocyte granule proteinase granzyme B (graB) and is...
5.
The intracellular serpin proteinase inhibitor 6 is expressed in monocytes and granulocytes and is a potent inhibitor of the azurophilic granule protease, cathepsin G
Scott F, Hirst C, Sun J, Bird C, Bottomley S, Bird P
Blood . 1999 Mar; 93(6):2089-97. PMID: 10068683
The monocyte and granulocyte azurophilic granule proteinases elastase, proteinase 3, and cathepsin G are implicated in acute and chronic diseases thought to result from an imbalance between the secreted proteinase(s)...
6.
Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
Bird C, Sutton V, Sun J, Hirst C, Novak A, Kumar S, et al.
Mol Cell Biol . 1998 Oct; 18(11):6387-98. PMID: 9774654
Cytotoxic lymphocytes (CLs) induce caspase activation and apoptosis of target cells either through Fas activation or through release of granule cytotoxins, particularly granzyme B. CLs themselves resist granule-mediated apoptosis but...