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C A Newton

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Articles 38
Citations 462
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Recent Articles
1.
Klein T, Newton C, Friedman H
Pain Res Manag . 2002 Feb; 6(2):95-101. PMID: 11854771
The effect of cannabimimetic agents on the function of immune cells such as T and B lymphocytes, natural killer cells and macrophages has been extensively studied over the past several...
2.
Klein T, Lane B, Newton C, Friedman H
Proc Soc Exp Biol Med . 2000 Sep; 225(1):1-8. PMID: 10998193
Many advances have been made in the last few years concerning our understanding of the receptors and ligands composing the cannabinoid system. Likewise, the science surrounding cytokine biology has advanced...
3.
McHugh S, Newton C, Yamamoto Y, Klein T, Friedman H
Proc Soc Exp Biol Med . 2000 Jun; 224(3):191-6. PMID: 10865236
Legionella pneumophila is an ubiquitous opportunistic intracellular pathogen that replicates readily in thioglycollate-elicited peritoneal macrophages from genetically susceptible A/J mice. Treatment of macrophage cultures in vitro with tumor necrosis factor-alpha...
4.
Klein T, Newton C, Nakachi N, Friedman H
J Immunol . 2000 Jun; 164(12):6461-6. PMID: 10843702
The marijuana cannabinoid, delta 9-tetrahydrocannabinol (THC), suppresses immunity to Legionella pneumophila and development of Th1 activity and cell-mediated immunity. In the current study, THC effects on cytokines regulating the development...
5.
Sutton E, Norman J, Rao P, Graham L, Newton C, Richards I
Shock . 2000 Feb; 13(2):117-25. PMID: 10670841
Previously we found the structural integrity of the aortic endothelium was maintained after the administration of endotoxin in type 1 interleukin-1 (IL-1) receptor knockout mice. In this study, we investigated...
6.
Sutton E, Thomas T, Bryant M, Landon C, Newton C, Rhodin J
J Submicrosc Cytol Pathol . 2000 Jan; 31(3):313-23. PMID: 10626000
A chronic inflammatory response possibly mediated by amyloid-beta (A beta) is believed to be a major factor in the pathology of Alzheimer's disease (AD). Recently, we demonstrated that in vivo...
7.
Sutton E, Norman J, Newton C, Hellermann G, Richards I
Shock . 1997 Feb; 7(2):105-10. PMID: 9035286
The derangement of arterial endothelial cell morphology is a good indicator of a severe shock state. Because interleukin (IL)-1 has been implicated in this process, we examined the structural integrity...
8.
Tan J, Newton C, Djeu J, Gutsch D, Chang A, Yang N, et al.
Cancer Res . 1996 Aug; 56(15):3399-403. PMID: 8758901
Interleukin (IL-12) protein has been shown to elicit diverse immunological responses and potent antitumor activity. We demonstrate here that intradermal injection of IL-12 cDNA induces systemic biological effects characteristic of...
9.
Newton C, Klein T, Friedman H
Infect Immun . 1994 Sep; 62(9):4015-20. PMID: 8063421
Resistance to infection with Legionella pneumophila is primarily dependent upon cell-mediated immunity rather than humoral immunity. Recent evidence suggests that activation of cell-mediated immunity depends on Th1 cells and activation...
10.
Gebran S, Newton C, Yamamoto Y, Klein T, Friedman H
J Clin Microbiol . 1994 Jan; 32(1):127-30. PMID: 8126166
A rapid colorimetric technique for in vitro quantitation of Legionella pneumophila intracellular proliferation in macrophages is described. The assay is based on the electron transport activity of metabolically active L....