C.A. Hitchcock
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Explore the profile of C.A. Hitchcock including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
902
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Recent Articles
1.
Sheehan D, Hitchcock C, Sibley C
Clin Microbiol Rev
. 1999 Jan;
12(1):40-79.
PMID: 9880474
Major developments in research into the azole class of antifungal agents during the 1990s have provided expanded options for the treatment of many opportunistic and endemic fungal infections. Fluconazole and...
2.
Orozco A, Higginbotham L, Hitchcock C, Parkinson T, Falconer D, Ibrahim A, et al.
Antimicrob Agents Chemother
. 1998 Oct;
42(10):2645-9.
PMID: 9756770
The mechanisms of fluconazole resistance in three clinical isolates of Candida krusei were investigated. Analysis of sterols of organisms grown in the absence and presence of fluconazole demonstrated that the...
3.
Koltin Y, Hitchcock C
Curr Opin Chem Biol
. 1997 Aug;
1(2):176-82.
PMID: 9667858
The first generation antifungal agent triazoles, fluconazole and itraconazole, have revolutionised the treatment of serious fungal infections such as mucosal and invasive candidiasis and cryptococcal meningitis. However, the treatment of...
4.
Martin M, Yates J, Hitchcock C
Antimicrob Agents Chemother
. 1997 Jan;
41(1):13-6.
PMID: 8980747
Left-sided Aspergillus fumigatus endocarditis was established in the guinea pig heart by catheterization and inoculation with conidia via a tributary of the femoral vein. This animal model was used to...
5.
Anaissie E, Paetznick V, Ensign L, Espinel-Ingroff A, Galgiani J, Hitchcock C, et al.
Antimicrob Agents Chemother
. 1996 Oct;
40(10):2387-91.
PMID: 8891149
The growth patterns observed in the trailing wells when fluconazole is being tested may give rise to readings that suggest resistance or increased MICs for known susceptible strains. We conducted...
6.
Baillie G, Hitchcock C, Burnet F
J Med Vet Mycol
. 1996 Sep;
34(5):341-7.
PMID: 8912168
Microsomal fractions were isolated from Aspergillus fumigatus cultures that had been treated with dimethylsulphoxide (DMSO), ethanol, benzopyrene, phenobarbital or naphthalene. All these xenobiotics increased microsomal cytochrome P-450 content. Cytochrome P-450...
7.
Field E, Millns B, Pearce P, Martin M, Parkinson T, Hitchcock C
J Med Vet Mycol
. 1996 Jun;
34(3):205-8.
PMID: 8803802
We report a case of oropharyngeal and oesophageal candidiasis in a 23-year-old man with endocrinopathy syndrome. Multiple episodes of infection were treated with topical miconazole, oral ketoconazole (200 mg daily)...
8.
Clark F, Parkinson T, Hitchcock C, Gow N
Antimicrob Agents Chemother
. 1996 Feb;
40(2):419-25.
PMID: 8834890
A wide variety of prokaryotic and eukaryotic cells exhibit a multidrug resistance (MDR) phenotype, indicating that resistance to potentially toxic compounds is mediated by their active efflux from the cell....
9.
Geber A, Hitchcock C, Swartz J, Pullen F, Marsden K, Kwon-Chung K, et al.
Antimicrob Agents Chemother
. 1995 Dec;
39(12):2708-17.
PMID: 8593007
We have cloned and sequenced the structural genes encoding the delta 5,6 sterol desaturase (ERG3 gene) and the 14 alpha-methyl sterol demethylase (ERG11 gene) from Candida glabrata L5 (leu2). Single...
10.
Parkinson T, Falconer D, Hitchcock C
Antimicrob Agents Chemother
. 1995 Aug;
39(8):1696-9.
PMID: 7486903
We report on the mechanism of fluconazole resistance in Candida glabrata from a case of infection in which pre- and posttreatment isolates were available for comparison. The resistant, posttreatment isolate...