Bunsyo Shiotani
Overview
Explore the profile of Bunsyo Shiotani including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
26
Citations
1033
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0
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Recent Articles
1.
Yano K, Kato M, Endo S, Igarashi T, Wada R, Kohno T, et al.
Cell Death Discov
. 2025 Jan;
11(1):31.
PMID: 39875375
DNA replication stress (RS), a prevalent feature of various malignancies, arises from both genetic mutations and genotoxic exposure. Elevated RS levels increase the vulnerability of cancer cells to ataxia telangiectasia...
2.
Igarashi T, Yano K, Endo S, Shiotani B
Cancers (Basel)
. 2024 Oct;
16(20).
PMID: 39456601
Activation of oncogenes disturbs a wide variety of cellular processes and induces physiological dysregulation of DNA replication, widely referred to as replication stress (RS). Oncogene-induced RS can cause replication forks...
3.
Igarashi T, Mazevet M, Yasuhara T, Yano K, Mochizuki A, Nishino M, et al.
Nat Commun
. 2023 Aug;
14(1):4991.
PMID: 37591859
Activation of the KRAS oncogene is a source of replication stress, but how this stress is generated and how it is tolerated by cancer cells remain poorly understood. Here we...
4.
Uchida C, Niida H, Sakai S, Iijima K, Kitagawa K, Ohhata T, et al.
Biochim Biophys Acta Mol Cell Res
. 2023 May;
1870(6):119484.
PMID: 37201767
Ataxia-telangiectasia mutated and Rad3-related (ATR) kinase is a crucial regulator of the cell cycle checkpoint and activated in response to DNA replication stress by two independent pathways via RPA32-ETAA1 and...
5.
Yano K, Shiotani B
Cancer Sci
. 2023 May;
114(7):2709-2721.
PMID: 37189251
DNA replication stress (RS) causes genomic instability and vulnerability in cancer cells. To counteract RS, cells have evolved various mechanisms involving the ATR kinase signaling pathway, which regulates origin firing,...
6.
Kurashima K, Kashiwagi H, Shimomura I, Suzuki A, Takeshita F, Mazevet M, et al.
NAR Cancer
. 2021 Jul;
2(2):zcaa005.
PMID: 34316685
The SWI/SNF chromatin remodeling complex regulates transcription through the control of chromatin structure and is increasingly thought to play an important role in human cancer. Lung adenocarcinoma (LADC) patients frequently...
7.
Yano K, Takahashi R, Shiotani B, Abe J, Shidooka T, Sudo Y, et al.
J Biol Chem
. 2021 Jun;
297(1):100882.
PMID: 34144037
Alteration of RNA splicing is a hallmark of cellular senescence, which is associated with age-related disease and cancer development. However, the roles of splicing factors in cellular senescence are not...
8.
Yasuhara T, Kato R, Hagiwara Y, Shiotani B, Yamauchi M, Nakada S, et al.
Cell
. 2018 Sep;
175(2):558-570.e11.
PMID: 30245011
Given that genomic DNA exerts its function by being transcribed, it is critical for the maintenance of homeostasis that DNA damage, such as double-strand breaks (DSBs), within transcriptionally active regions...
9.
Matsunuma R, Niida H, Ohhata T, Kitagawa K, Sakai S, Uchida C, et al.
Mol Cell Biol
. 2018 Mar;
38(7).
PMID: 29545385
No abstract available.
10.
Asano N, Yoshida A, Mitani S, Kobayashi E, Shiotani B, Komiyama M, et al.
Oncotarget
. 2017 Jan;
8(8):12941-12952.
PMID: 28099935
Well-differentiated liposarcoma (WDLPS) and dedifferentiated liposarcoma (DDLPS) are closely related tumors commonly characterized by MDM2/CDK4 gene amplification, and lack clinically effective treatment options when inoperable. To identify novel therapeutic targets,...