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Bum-Joon Park

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Articles 71
Citations 1461
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Recent Articles
1.
Chung Y, Park S, Lee M, Lee J, Ji Y, Song Y, et al.
Neuro Oncol . 2024 Dec; PMID: 39731295
Background: NF2-related schwannomatosis (NF2-SWN) is associated with multiple benign tumors in the nervous system. NF2-SWN, caused by mutations in the NF2 gene, has developed into intracranial and spinal schwannomas. Because...
2.
Park S, Oh A, Hong B, Shin Y, Jang H, Seo H, et al.
Mol Ther Oncol . 2024 Oct; 32(4):200875. PMID: 39351074
Alternative splicing products of AIMP2 and AIMP2-DX2 (DX2) have been reported to be associated with human lung cancer. In fact, DX2 expression is elevated in human lung cancers, and DX2...
3.
Kim B, Chung Y, Woo T, Kang S, Park S, Kim M, et al.
Int J Mol Sci . 2024 Jun; 25(12). PMID: 38928264
NF2-related schwannomatosis (NF2) is a genetic syndrome characterized by the growth of benign tumors in the nervous system, particularly bilateral vestibular schwannomas, meningiomas, and ependymomas. This review consolidates the current...
4.
Kim B, Chung Y, Woo T, Kang S, Park S, Park B
Cells . 2023 Sep; 12(18). PMID: 37759521
Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused by the mutant protein progerin, which is expressed by the abnormal splicing of the gene. HGPS affects systemic levels,...
5.
Kang S, Seo S, Song E, Kweon O, Jo A, Park S, et al.
Cells . 2023 May; 12(9). PMID: 37174632
Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare human premature aging disorder that precipitates death because of cardiac disease. Almost all cases of HGPS are caused by aberrant splicing of the...
6.
Sim J, Lee A, Kim D, Kim K, Park B, Park K, et al.
Small . 2023 Feb; 19(21):e2208088. PMID: 36843266
Protein mutations alter protein-protein interactions that can lead to a number of illnesses. Mutations in lamin A (LMNA) have been reported to cause laminopathies. However, the proteins associated with the...
7.
Ahn J, Lee J, Jeong S, Jo I, Kang S, Park B, et al.
Biochem Biophys Res Commun . 2022 Nov; 637:210-217. PMID: 36403485
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by C-terminally truncated lamin A, termed as the pre-progerin product. Progerin is a C-terminally farnesylated protein derived from pre-progerin, which...
8.
Baek Y, Woo T, Ahn J, Lee D, Kwon Y, Park B, et al.
Commun Biol . 2022 Oct; 5(1):1085. PMID: 36224351
Eukaryotic Cu, Zn-superoxide dismutase (SOD1) is primarily responsible for cytotoxic filament formation in amyotrophic lateral sclerosis (ALS) neurons. Two cysteine residues in SOD1 form an intramolecular disulfide bond. This study...
9.
Jeong S, Ahn J, Jo I, Kang S, Park B, Cho H, et al.
J Biol Chem . 2022 Jul; 298(9):102256. PMID: 35839855
Nuclear lamins maintain the nuclear envelope structure by forming long linear filaments via two alternating molecular arrangements of coiled-coil dimers, known as A11 and A22 binding modes. The A11 binding...
10.
Ahn J, Jeong S, Kang S, Jo I, Park B, Ha N
Commun Biol . 2022 Mar; 5(1):267. PMID: 35338226
Lamins are intermediate filaments that form a 3-D meshwork in the periphery of the nuclear envelope. The recent crystal structure of a long fragment of human lamin A/C visualized the...