Brydie R Huckestein
Overview
Explore the profile of Brydie R Huckestein including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
203
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0
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Recent Articles
1.
Huckestein B, Antos D, Manni M, Zeng K, Miller L, Parenteau K, et al.
Am J Physiol Lung Cell Mol Physiol
. 2024 May;
327(2):L189-L202.
PMID: 38810239
Children are susceptible to influenza infections and can experience severe disease presentation due to a lack of or limited pre-existing immunity. Despite the disproportionate impact influenza has on this population,...
2.
Huckestein B, Zeng K, Westcott R, Alder J, Antos D, Kolls J, et al.
Am J Pathol
. 2023 Dec;
194(3):384-401.
PMID: 38159723
Respiratory tract virus infections cause millions of hospitalizations worldwide each year. Severe infections lead to lung damage that coincides with persistent inflammation and a lengthy repair period. Vaccination and antiviral...
3.
Gocher-Demske A, Cui J, Szymczak-Workman A, Vignali K, Latini J, Pieklo G, et al.
Nat Immunol
. 2023 Mar;
24(5):841-854.
PMID: 36928412
Regulatory T (T) cells are an immunosuppressive population that are required to maintain peripheral tolerance and prevent tissue damage from immunopathology, via anti-inflammatory cytokines, inhibitor receptors and metabolic disruption. Here...
4.
Cipolla E, Yue M, Nickolich K, Huckestein B, Antos D, Chen W, et al.
J Immunol
. 2022 Aug;
209(4):760-771.
PMID: 35914833
Influenza-associated bacterial superinfections have devastating impacts on the lung and can result in increased risk of mortality. New strains of influenza circulate throughout the population yearly, promoting the establishment of...
5.
Xie B, Ramirez W, Mills A, Huckestein B, Anderson M, Pangburn M, et al.
Curr Res Physiol
. 2022 Jun;
5:232-239.
PMID: 35677213
Sodium-glucose co-transporter type 2 (SGLT2) inhibitor therapy to treat type 2 diabetes unexpectedly reduced all-cause mortality and hospitalization due to heart failure in several large-scale clinical trials, and has since...
6.
Huckestein B, Alcorn J
Am J Respir Cell Mol Biol
. 2022 Apr;
66(6):598-600.
PMID: 35442855
No abstract available.
7.
Bhattacharjee A, Burr A, Overacre-Delgoffe A, Tometich J, Yang D, Huckestein B, et al.
Immunity
. 2021 Aug;
54(8):1745-1757.e7.
PMID: 34348118
Environmental enteric dysfunction (EED) is a gastrointestinal inflammatory disease caused by malnutrition and chronic infection. EED is associated with stunting in children and reduced efficacy of oral vaccines. To study...
8.
Liu Y, Jurczak M, Lear T, Lin B, Larsen M, Kennerdell J, et al.
Nat Chem Biol
. 2021 Jan;
17(3):298-306.
PMID: 33495648
The adenosine monophosphate (AMP)-activated protein kinase (Ampk) is a central regulator of metabolic pathways, and increasing Ampk activity has been considered to be an attractive therapeutic target. Here, we have...
9.
Edmunds L, Xie B, Mills A, Huckestein B, Undamatla R, Murali A, et al.
Mol Metab
. 2020 Jul;
41:101051.
PMID: 32653576
Objective: PARKIN is an E3 ubiquitin ligase that regulates mitochondrial quality control through a process called mitophagy. Recent human and rodent studies suggest that loss of hepatic mitophagy may occur...
10.
Cipolla E, Huckestein B, Alcorn J
Clin Sci (Lond)
. 2020 Jul;
134(13):1697-1714.
PMID: 32648583
Acute influenza virus infections are a global public health concern accounting for millions of illnesses worldwide ranging from mild to severe with, at time, severe complications. Once an individual is...