Bryan Zeitler
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Explore the profile of Bryan Zeitler including associated specialties, affiliations and a list of published articles.
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13
Citations
2622
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Recent Articles
1.
Persistent repression of tau in the brain using engineered zinc finger protein transcription factors
Wegmann S, DeVos S, Zeitler B, Marlen K, Bennett R, Perez-Rando M, et al.
Sci Adv
. 2021 Mar;
7(12).
PMID: 33741591
Neuronal tau reduction confers resilience against β-amyloid and tau-related neurotoxicity in vitro and in vivo. Here, we introduce a novel translational approach to lower expression of the tau gene at...
2.
Zeitler B, Froelich S, Marlen K, Shivak D, Yu Q, Li D, et al.
Nat Med
. 2019 Jul;
25(7):1131-1142.
PMID: 31263285
Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin gene (HTT), which codes for the pathologic mutant HTT (mHTT) protein. Since...
3.
Ainley W, Sastry-Dent L, Welter M, Murray M, Zeitler B, Amora R, et al.
Plant Biotechnol J
. 2013 Aug;
11(9):1126-34.
PMID: 23953646
Modern agriculture demands crops carrying multiple traits. The current paradigm of randomly integrating and sorting independently segregating transgenes creates severe downstream breeding challenges. A versatile, generally applicable solution is hereby...
4.
Li J, Blue R, Zeitler B, Strange T, Pearl J, Huizinga D, et al.
Plant Biotechnol J
. 2013 Mar;
11(6):671-80.
PMID: 23521778
Targeted gene regulation via designed transcription factors has great potential for precise phenotypic modification and acceleration of novel crop trait development. To this end, designed transcriptional activators have been constructed...
5.
Straimer J, Lee M, Lee A, Zeitler B, Williams A, Pearl J, et al.
Nat Methods
. 2012 Aug;
9(10):993-8.
PMID: 22922501
Malaria afflicts over 200 million people worldwide, and its most lethal etiologic agent, Plasmodium falciparum, is evolving to resist even the latest-generation therapeutics. Efficient tools for genome-directed investigations of P....
6.
Hockemeyer D, Wang H, Kiani S, Lai C, Gao Q, Cassady J, et al.
Nat Biotechnol
. 2011 Jul;
29(8):731-4.
PMID: 21738127
Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here we engineered transcription activator-like effector...
7.
Wood A, Lo T, Zeitler B, Pickle C, Ralston E, Lee A, et al.
Science
. 2011 Jun;
333(6040):307.
PMID: 21700836
Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy...
8.
Flisikowska T, Thorey I, Offner S, Ros F, Lifke V, Zeitler B, et al.
PLoS One
. 2011 Jun;
6(6):e21045.
PMID: 21695153
Rabbits are widely used in biomedical research, yet techniques for their precise genetic modification are lacking. We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can inactivate a...
9.
Young J, Cherone J, Doyon Y, Ankoudinova I, Faraji F, Lee A, et al.
Proc Natl Acad Sci U S A
. 2011 Apr;
108(17):7052-7.
PMID: 21471457
The frog Xenopus, an important research organism in cell and developmental biology, currently lacks tools for targeted mutagenesis. Here, we address this problem by genome editing with zinc-finger nucleases (ZFNs)....
10.
Doyon J, Zeitler B, Cheng J, Cheng A, Cherone J, Santiago Y, et al.
Nat Cell Biol
. 2011 Feb;
13(3):331-7.
PMID: 21297641
Clathrin-mediated endocytosis (CME) is the best-studied pathway by which cells selectively internalize molecules from the plasma membrane and surrounding environment. Previous live-cell imaging studies using ectopically overexpressed fluorescent fusions of...