Bryan T Phillips
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Explore the profile of Bryan T Phillips including associated specialties, affiliations and a list of published articles.
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20
Citations
383
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Recent Articles
11.
Baldwin A, Clemons A, Phillips B
J Cell Sci
. 2016 Jan;
129(5):983-93.
PMID: 26795562
The Wnt/β-catenin signaling pathway is utilized across metazoans. However, the mechanism of signal transduction, especially dissociation of the β-catenin destruction complex by Dishevelled proteins, remains controversial. Here, we describe the...
12.
Mila D, Calderon A, Baldwin A, Moore K, Watson M, Phillips B, et al.
Genetics
. 2015 Sep;
201(3):1047-60.
PMID: 26358719
Asymmetric cell division is critical during development, as it influences processes such as cell fate specification and cell migration. We have characterized FRK-1, a homolog of the mammalian Fer nonreceptor...
13.
Vora S, Phillips B
Curr Biol
. 2015 Mar;
25(8):1005-16.
PMID: 25819561
Caenorhabditis elegans embryos rapidly diversify cell fate using a modified Wnt/β-catenin signaling strategy to carry out serial asymmetric cell divisions (ACDs). Wnt-dependent ACDs rely on nuclear asymmetry of the transcriptional...
14.
Baldwin A, Phillips B
J Cell Sci
. 2014 Apr;
127(Pt 12):2771-81.
PMID: 24762815
The APC tumor suppressor regulates diverse stem cell processes including gene regulation through Wnt-β-catenin signaling and chromosome stability through microtubule interactions, but how the disparate functions of APC are controlled...
15.
Phillips B, Kimble J
Dev Cell
. 2009 Jul;
17(1):27-34.
PMID: 19619489
The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual...
16.
Chesney M, Lam N, Morgan D, Phillips B, Kimble J
Dev Biol
. 2009 Apr;
331(1):14-25.
PMID: 19376107
The Caenorhabditis elegans distal tip cell (DTC) provides a niche for germline stem cells in both hermaphrodites and males. The hermaphrodite distal tip cell (hDTC) also provides "leader" function to...
17.
Liu J, Phillips B, Amaya M, Kimble J, Xu W
Dev Cell
. 2008 May;
14(5):751-61.
PMID: 18477457
C. elegans SYS-1 has key functional characteristics of a canonical beta-catenin, but no significant sequence similarity. Here, we report the SYS-1 crystal structure, both on its own and in a...
18.
Phillips B, Kidd 3rd A, King R, Hardin J, Kimble J
Proc Natl Acad Sci U S A
. 2007 Feb;
104(9):3231-6.
PMID: 17296929
beta-Catenins are conserved regulators of metazoan development that function with TCF DNA-binding proteins to activate transcription. In Caenorhabditis elegans, SYS-1/beta-catenin and POP-1/TCF regulate several asymmetric divisions, including that of the...
19.
Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B
Dev Biol
. 2006 Apr;
294(2):376-90.
PMID: 16631154
The zebrafish muscle segment homeobox genes msxB, msxC and msxE are expressed in partially overlapping domains in the neural crest and preplacodal ectoderm. We examined the roles of these msx...
20.
Phillips B, Storch E, Lekven A, Riley B
Development
. 2004 Feb;
131(4):923-31.
PMID: 14757644
Induction of the otic placode, which gives rise to all tissues comprising the inner ear, is a fundamental aspect of vertebrate development. A number of studies indicate that fibroblast growth...