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Bryan C Frank

Explore the profile of Bryan C Frank including associated specialties, affiliations and a list of published articles. Areas
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Articles 19
Citations 1166
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Recent Articles
1.
Jones M, Nierman W, Shan Y, Frank B, Spoering A, Ling L, et al.
Microb Ecol . 2016 Nov; 73(3):658-667. PMID: 27896376
Most antibiotics were discovered by screening soil actinomycetes, but the efficiency of the discovery platform collapsed in the 1960s. By now, more than 3000 antibiotics have been described and most...
2.
Jones M, Montgomery C, Boyle-Vavra S, Shatzkes K, Maybank R, Frank B, et al.
BMC Genomics . 2014 Dec; 15:1145. PMID: 25527145
Background: Staphylococcus aureus is a human pathogen responsible for substantial morbidity and mortality through its ability to cause a number of human infections including bacteremia, pneumonia and soft tissue infections....
3.
Deatherage Kaiser B, Li J, Sanford J, Kim Y, Kronewitter S, Jones M, et al.
PLoS One . 2013 Jul; 8(6):e67155. PMID: 23840608
The potential for commensal microorganisms indigenous to a host (the 'microbiome' or 'microbiota') to alter infection outcome by influencing host-pathogen interplay is largely unknown. We used a multi-omics "systems" approach,...
4.
Ansong C, Schrimpe-Rutledge A, Mitchell H, Chauhan S, Jones M, Kim Y, et al.
Mol Biosyst . 2012 Nov; 9(1):44-54. PMID: 23147219
The underlying mechanisms that lead to dramatic differences between closely related pathogens are not always readily apparent. For example, the genomes of Yersinia pestis (YP) the causative agent of plague...
5.
Bordbar A, Mo M, Nakayasu E, Schrimpe-Rutledge A, Kim Y, Metz T, et al.
Mol Syst Biol . 2012 Jun; 8:558. PMID: 22735334
Macrophages are central players in immune response, manifesting divergent phenotypes to control inflammation and innate immunity through release of cytokines and other signaling factors. Recently, the focus on metabolism has...
6.
Schrimpe-Rutledge A, Jones M, Chauhan S, Purvine S, Sanford J, Monroe M, et al.
PLoS One . 2012 Apr; 7(3):e33903. PMID: 22479471
Genome sequencing continues to be a rapidly evolving technology, yet most downstream aspects of genome annotation pipelines remain relatively stable or are even being abandoned. The annotation process is now...
7.
Joe B, Saad Y, Dhindaw S, Lee N, Frank B, Achinike O, et al.
Hum Mol Genet . 2009 May; 18(15):2825-38. PMID: 19423552
A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained only two...
8.
Jung K, Dardick C, Bartley L, Cao P, Phetsom J, Canlas P, et al.
PLoS One . 2008 Oct; 3(10):e3337. PMID: 18836531
Studies of gene function are often hampered by gene-redundancy, especially in organisms with large genomes such as rice (Oryza sativa). We present an approach for using transcriptomics data to focus...
9.
Liang M, Lee N, Wang H, Greene A, Kwitek A, Kaldunski M, et al.
Physiol Genomics . 2008 Apr; 34(1):54-64. PMID: 18430809
The Dahl salt-sensitive (SS) rat is a widely used model of human salt-sensitive hypertension and renal injury. We studied the molecular networks that underlie the complex disease phenotypes in the...
10.
Toland E, Saad Y, Yerga-Woolwine S, Ummel S, Farms P, Ramdath R, et al.
Mamm Genome . 2008 Mar; 19(3):209-18. PMID: 18324438
There is enough evidence through linkage and substitution mapping to indicate that rat chromosome 1 harbors multiple blood pressure (BP) quantitative trait loci (QTLs). Of these, BP QTL1b was previously...