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Bruz Marzolf

Explore the profile of Bruz Marzolf including associated specialties, affiliations and a list of published articles. Areas
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Articles 17
Citations 1566
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Recent Articles
1.
Patra B, Kon Y, Yadav G, Sevold A, Frumkin J, Vallabhajosyula R, et al.
Nucleic Acids Res . 2016 Dec; 45(1):255-270. PMID: 27899637
Genomic robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of genomic robustness in budding yeast by genome...
2.
Burdick D, Cavnor C, Handcock J, Killcoyne S, Lin J, Marzolf B, et al.
BMC Bioinformatics . 2010 Jul; 11:377. PMID: 20630057
Background: High throughput sequencing has become an increasingly important tool for biological research. However, the existing software systems for managing and processing these data have not provided the flexible infrastructure...
3.
Gehlenborg N, Hwang D, Lee I, Yoo H, Baxter D, Petritis B, et al.
Database (Oxford) . 2010 Feb; 2009:bap011. PMID: 20157484
Prion diseases reflect conformational conversion of benign isoforms of prion protein (PrP(C)) to malignant PrP(Sc) isoforms. Networks perturbed by PrP(Sc) accumulation and their ties to pathological events are poorly understood....
4.
Pascal L, Vencio R, Page L, Liebeskind E, Shadle C, Troisch P, et al.
BMC Cancer . 2009 Dec; 9:452. PMID: 20021671
Background: Prostate cancer cells in primary tumors have been typed CD10-/CD13-/CD24hi/CD26+/CD38lo/CD44-/CD104-. This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of tumors is...
5.
Koide T, Reiss D, Bare J, Pang W, Facciotti M, Schmid A, et al.
Mol Syst Biol . 2009 Jun; 5:285. PMID: 19536208
Despite the knowledge of complex prokaryotic-transcription mechanisms, generalized rules, such as the simplified organization of genes into operons with well-defined promoters and terminators, have had a significant role in systems...
6.
Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, et al.
Proc Natl Acad Sci U S A . 2009 Feb; 106(11):4402-7. PMID: 19246379
Drug-induced liver injury is a frequent side effect of many drugs, constitutes a significant threat to patient health and has an enormous economic impact on health care expenditures. Numerous efforts...
7.
Wu Z, Jia X, de la Cruz L, Su X, Marzolf B, Troisch P, et al.
Immunity . 2008 Dec; 29(6):863-75. PMID: 19100700
Differentiation of memory cells involves DNA-sequence changes in B lymphocytes but is less clearly defined in T cells. RNA rearrangement is identified here as a key event in memory T...
8.
Querec T, Akondy R, Lee E, Cao W, Nakaya H, Teuwen D, et al.
Nat Immunol . 2008 Nov; 10(1):116-125. PMID: 19029902
A major challenge in vaccinology is to prospectively determine vaccine efficacy. Here we have used a systems biology approach to identify early gene 'signatures' that predicted immune responses in humans...
9.
Korb M, Rust A, Thorsson V, Battail C, Li B, Hwang D, et al.
BMC Immunol . 2008 Mar; 9:7. PMID: 18321385
Background: As part of a National Institute of Allergy and Infectious Diseases funded collaborative project, we have performed over 150 microarray experiments measuring the response of C57/BL6 mouse bone marrow...
10.
Smith J, Ramsey S, Marelli M, Marzolf B, Hwang D, Saleem R, et al.
Mol Syst Biol . 2007 Jun; 3:115. PMID: 17551510
In transcriptional regulatory networks, the coincident binding of a combination of factors to regulate a gene implies the existence of complex mechanisms to control both the gene expression profile and...