Bruno M F Goncalves
Overview
Explore the profile of Bruno M F Goncalves including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
126
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Recent Articles
1.
Ribeiro J, Szemeredi N, Goncalves B, Spengler G, Afonso C, Ferreira M
RSC Med Chem
. 2024 Apr;
15(4):1348-1361.
PMID: 38665830
Multidrug resistance (MDR) remains a challenging issue in cancer treatment. Aiming at finding anticancer agents to overcome MDR, the triacetyl derivative (2) of the labdane diterpenoid lactone andrographolide (1) underwent...
2.
Gomes R, Goncalves B, Andrade K, Sousa B, Maulide N, Bernardes G, et al.
Angew Chem Int Ed Engl
. 2023 May;
62(28):e202304449.
PMID: 37142557
The demand for new biomass-derived fine and commodity chemicals propels the discovery of new methodologies and synthons. Whereas furfural and 5-hydroxymethylfurfural are cornerstones of sustainable chemistry, 3-acetamido-5-acetyl furan (3A5AF), an...
3.
Goncalves B, Mendes V, Silvestre S, Salvador J
RSC Med Chem
. 2023 Feb;
14(2):313-331.
PMID: 36846362
Arjunolic acid (AA) is a pentacyclic triterpenoid with promising anticancer properties. A series of novel AA derivatives containing a pentameric A-ring with an enal moiety, combined with additional modifications at...
4.
Ramalhete C, Goncalves B, Barbosa F, Duarte N, Ferreira M
Phytochem Rev
. 2022 Feb;
21(2):617-646.
PMID: 35153639
L. (Cucurbitaceae), frequently named balsam apple, southern balsam pear or African pumpkin, is a vegetable with high nutritional value, being mostly used as food in sub-Saharan Africa. It has also...
5.
Goncalves B, Cardoso D, Ferreira M
Molecules
. 2020 Jul;
25(15).
PMID: 32722234
Multidrug resistance (MDR) in cancer is one of the main limitations for chemotherapy success. Numerous mechanisms are behind the MDR phenomenon wherein the overexpression of the ATP-binding cassette (ABC) transporter...
6.
Salvador J, Leal A, Valdeira A, Goncalves B, Alho D, Figueiredo S, et al.
Eur J Med Chem
. 2017 Jul;
142:95-130.
PMID: 28754470
Natural pentacyclic triterpenoids (PTs) have been often reported to exhibit a wide range of biological activities. Among them, the anticancer and anti-inflammatory activities are the most studied. Over the last...
7.
Goncalves B, Salvador J, Marin S, Cascante M
Eur J Med Chem
. 2016 Mar;
114:101-17.
PMID: 26974379
A series of novel fluorinated Asiatic Acid (AA) derivatives were successfully synthesized, tested for their antiproliferative activity against HeLa and HT-29 cell lines, and their structure activity relationships were evaluated....
8.
Salvador J, Moreira V, Goncalves B, Leal A, Jing Y
Nat Prod Rep
. 2012 Oct;
29(12):1463-79.
PMID: 23047641
This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of...