Bruno Kyewski
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Explore the profile of Bruno Kyewski including associated specialties, affiliations and a list of published articles.
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64
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3897
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Recent Articles
1.
Gonzalez-Duque S, Azoury M, Colli M, Afonso G, Turatsinze J, Nigi L, et al.
Cell Metab
. 2018 Aug;
28(6):946-960.e6.
PMID: 30078552
Although CD8 T-cell-mediated autoimmune β cell destruction occurs in type 1 diabetes (T1D), the target epitopes processed and presented by β cells are unknown. To identify them, we combined peptidomics...
2.
Miller C, Proekt I, von Moltke J, Wells K, Rajpurkar A, Wang H, et al.
Nature
. 2018 Jul;
559(7715):627-631.
PMID: 30022164
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although the thymic medulla consists mostly of developing and mature AIRE epithelial cells, recent evidence has...
3.
Michel C, Kuchler R, Martin I, Kyewski B, Pinto S
J Immunol Methods
. 2018 Apr;
457:82-86.
PMID: 29605230
The study of organogenesis, tissue-homeostasis and regeneration requires the precise assessment of in vivo cell proliferation. To this end a host of methods have been developed to detect and quantify...
4.
Culina S, Lalanne A, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, et al.
Sci Immunol
. 2018 Feb;
3(20).
PMID: 29429978
The human leukocyte antigen-A2 (HLA-A2)-restricted zinc transporter 8 (ZnT8) and other islet epitopes elicit interferon-γ secretion by CD8 T cells preferentially in type 1 diabetes (T1D) patients compared with controls....
5.
Raposo B, Merky P, Lundqvist C, Yamada H, Urbonaviciute V, Niaudet C, et al.
Nat Commun
. 2018 Jan;
9(1):353.
PMID: 29367624
Establishing effective central tolerance requires the promiscuous expression of tissue-restricted antigens by medullary thymic epithelial cells. However, whether central tolerance also extends to post-translationally modified proteins is not clear. Here...
6.
Wang L, Winnewisser J, Federle C, Jessberger G, Nave K, Werner H, et al.
Front Immunol
. 2017 Nov;
8:1511.
PMID: 29170668
Immunization with myelin components can elicit experimental autoimmune encephalomyelitis (EAE). EAE susceptibility varies between mouse strains, depending on the antigen employed. BL/6 mice are largely resistant to EAE induction with...
7.
Michel C, Miller C, Kuchler R, Brors B, Anderson M, Kyewski B, et al.
J Immunol
. 2017 Oct;
199(10):3488-3503.
PMID: 28993517
The basic two-step terminal differentiation model of the medullary thymic epithelial cell (mTEC) lineage from immature MHC class II (MHCII) to mature MHCII mTECs has recently been extended to include...
8.
Brunk F, Michel C, Holland-Letz T, Slynko A, Kopp-Schneider A, Kyewski B, et al.
Eur J Immunol
. 2017 Apr;
47(7):1153-1159.
PMID: 28439878
The origin of the thymic epithelium, i.e. the cortical (cTEC) and medullary (mTEC) epithelial cells, from bipotent stem cells through TEC progenitors and lineage-specific progeny still remains poorly understood. We...
9.
Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, et al.
Cell Rep
. 2016 Oct;
17(2):448-457.
PMID: 27705793
Adult tissue-specific stem cells (SCs) mediate tissue homeostasis and regeneration and can give rise to all lineages in the corresponding tissue, similar to the early progenitors that generate organs in...
10.
Lucca L, Axisa P, Aloulou M, Perals C, Ramadan A, Rufas P, et al.
Eur J Immunol
. 2016 Jun;
46(9):2247-59.
PMID: 27334749
T-cell polyspecificity, predicting that individual T cells recognize a continuum of related ligands, implies that multiple antigens can tolerize T cells specific for a given self-antigen. We previously showed in...