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Bruno Flamion

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Articles 58
Citations 1399
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Recent Articles
1.
Idouz K, Belhaj A, Rondelet B, Dewachter L, Flamion B, Kirschvink N, et al.
Front Cell Dev Biol . 2024 Aug; 12:1449209. PMID: 39165663
Brain death (BD) is a complex medical state that triggers systemic disturbances and a cascade of pathophysiological processes. This condition significantly impairs both kidney function and structural integrity, thereby presenting...
2.
Phillips-Beyer A, Kawata A, Kleinman L, Seboek Kinter D, Flamion B
Pharmaceut Med . 2024 Feb; 38(2):133-144. PMID: 38302765
Background: The Sleep Diary Questionnaire (SDQ), a modified version of the Consensus Sleep Diary, is a 17-item sleep diary for assessing subjective total sleep time (sTST: total time spent asleep...
3.
Collacott H, Phillips-Beyer A, Krucien N, Flamion B, Marsh K
Patient . 2024 Jan; 17(3):287-300. PMID: 38270788
Background: Symptoms of systemic lupus erythematosus (SLE) vary between patients, but those of increased disease activity typically include musculoskeletal and mucocutaneous manifestations such as joint pain, swelling, and rashes. Several...
4.
Barrueta Tenhunen A, van der Heijden J, Dogne S, Flamion B, Weigl W, Frithiof R, et al.
Shock . 2023 Feb; 59(5):763-770. PMID: 36809365
While fluid resuscitation is fundamental in the treatment of sepsis-induced tissue hypoperfusion, a sustained positive fluid balance is associated with excess mortality. Hyaluronan, an endogenous glycosaminoglycan with high affinity to...
5.
Puissant E, Gilis F, Tevel V, Vandeweerd J, Flamion B, Jadot M, et al.
Sci Rep . 2022 Jun; 12(1):10142. PMID: 35710820
Mucopolysaccharidosis IX is a lysosomal storage disorder caused by a deficiency in HYAL1, an enzyme that degrades hyaluronic acid at acidic pH. This disease causes juvenile arthritis in humans and...
6.
Evrard C, Faway E, De Vuyst E, Svensek O, De Glas V, Bergerat D, et al.
JID Innov . 2021 Dec; 1(4):100054. PMID: 34909750
TSG-6 is a soluble protein secreted in the extracellular matrix by various cell types in response to inflammatory stimuli. TSG-6 interacts with extracellular matrix molecules, particularly hyaluronan (HA), and promotes...
7.
Marmol D, Holtze S, Kichler N, Sahm A, Bihin B, Bourguignon V, et al.
Sci Rep . 2021 Apr; 11(1):7951. PMID: 33846452
Large amounts of ultra-high molecular weight hyaluronan (HA) have been described as the main cause of cancer resistance in naked mole-rats (Heterocephalus glaber, NMR). Our work examined HA metabolism in...
8.
Heidenreich S, Phillips-Beyer A, Flamion B, Ross M, Seo J, Marsh K
Patient . 2020 Nov; 14(1):65-74. PMID: 33174080
Background: Studies recommend randomising the order of attributes in discrete choice experiments (DCEs) to avoid bias; however, in a benefit-risk setting, this may increase the cognitive burden of respondents who...
9.
Gueneau de Mussy P, Sidharta P, Wuerzner G, Maillard M, Guerard N, Iglarz M, et al.
Clin Pharmacol Ther . 2020 Sep; 109(3):746-753. PMID: 32897570
Aprocitentan is a novel, oral, dual endothelin receptor antagonist (ERA) in development in difficult-to-control hypertension. As fluid retention and edema are concerns with ERAs, we investigated whether aprocitentan causes weight...
10.
Verweij P, Danaietash P, Flamion B, Menard J, Bellet M
Hypertension . 2020 Feb; 75(4):956-965. PMID: 32063059
This study examined the dose-response characteristics of aprocitentan, a dual endothelin A/endothelin B receptor antagonist, in patients with essential hypertension. In a randomized, double-blind, parallel study design, eligible patients with...