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Bruno Benedetti

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Recent Articles
1.
Benedetti B, Reisinger M, Hochwartner M, Gabriele G, Jakubecova D, Benedetti A, et al.
Aging Cell . 2023 Aug; 22(12):e13974. PMID: 37649323
Beyond the canonical neurogenic niches, there are dormant neuronal precursors in several regions of the adult mammalian brain. Dormant precursors maintain persisting post-mitotic immaturity from birth to adulthood, followed by...
2.
Ghibaudi M, Marchetti N, Vergnano E, La Rosa C, Benedetti B, Couillard-Despres S, et al.
Front Cell Neurosci . 2023 Aug; 17:1205173. PMID: 37576566
The recent identification of a population of non-newly born, prenatally generated "immature" neurons in the layer II of the piriform cortex (cortical immature neurons, cINs), raises questions concerning their maintenance...
3.
Benedetti B, Bieler L, Erhardt-Kreutzer C, Jakubecova D, Benedetti A, Reisinger M, et al.
Int J Mol Sci . 2023 Mar; 24(5). PMID: 36902146
A spinal cord injury (SCI) damages the axonal projections of neurons residing in the neocortex. This axotomy changes cortical excitability and results in dysfunctional activity and output of infragranular cortical...
4.
Benedetti B, Weidenhammer A, Reisinger M, Couillard-Despres S
Int J Mol Sci . 2022 May; 23(10). PMID: 35628434
After spinal cord injury (SCI), the destruction of spinal parenchyma causes permanent deficits in motor functions, which correlates with the severity and location of the lesion. Despite being disconnected from...
5.
Benedetti B, Couillard-Despres S
Front Neurosci . 2022 Apr; 16:877167. PMID: 35464307
Dormant non-proliferative neuronal precursors (dormant precursors) are a unique type of undifferentiated neuron, found in the adult brain of several mammalian species, including humans. Dormant precursors are fundamentally different from...
6.
Romanelli P, Bieler L, Heimel P, Skokic S, Jakubecova D, Kreutzer C, et al.
Front Cell Neurosci . 2022 Jan; 15:795008. PMID: 35046776
Local inflammation plays a pivotal role in the process of secondary damage after spinal cord injury. We recently reported that acute intravenous application of extracellular vesicles (EVs) secreted by human...
7.
Coviello S, Benedetti B, Jakubecova D, Belles M, Klimczak P, Gramuntell Y, et al.
Int J Mol Sci . 2021 Jun; 22(11). PMID: 34072166
Immature neurons are maintained in cortical regions of the adult mammalian brain. In rodents, many of these immature neurons can be identified in the piriform cortex based on their high...
8.
Benedetti B, Dannehl D, Janssen J, Corcelli C, Couillard-Despres S, Engelhardt M
Int J Mol Sci . 2020 Aug; 21(17). PMID: 32847128
Rodent neocortical neurons undergo prominent postnatal development and maturation. The process is associated with structural and functional maturation of the axon initial segment (AIS), the site of action potential initiation....
9.
Romanelli P, Bieler L, Scharler C, Pachler K, Kreutzer C, Zaunmair P, et al.
Front Neurol . 2019 Dec; 10:1225. PMID: 31849808
Spinal cord injury is characterized by initial neural tissue disruption that triggers secondary damage and extensive non-resolving inflammation, which aggravates loss of function and hinders recovery. The early onset of...
10.
Benedetti B, Dannehl D, Konig R, Coviello S, Kreutzer C, Zaunmair P, et al.
Cereb Cortex . 2019 Oct; 30(3):1499-1515. PMID: 31647533
The extent of functional maturation and integration of nonproliferative neuronal precursors, becoming neurons in the adult murine piriform cortex, is largely unexplored. We thus questioned whether precursors eventually become equivalent...